光学多普勒成像(Optical Doppler tomography,ODT)是一种结合了光学相干层析成像技术(Optical coherence tomography,OCT)和多普勒流速仪的非侵入、非接触的成像技术,能够实现对高散介质组织内部的血管分布和血液流速的探测。阐述了基于数字希尔伯特变换的相位分离多普勒光学相干层析成像技术的工作原理,并且通过对玻璃毛细管和生物芯片微通道管中聚苯乙烯溶液流速的实验测量,准确测量管内微粒缓慢移动时的多普勒频移量,获得了玻璃管内和生物芯片微通道管中流速分布曲线,证实了所提方法的可行性。获取的多普勒图像具有较高的空间分辨力和速度分辨力,在未来的临床应用中有潜在的应用价值。

Optical Doppler tomography (ODT) is a non-invasive and non-contact imaging technology which combines Doppler velocimetry with optical coherence tomography (OCT) for measuring blood flow velocity and blood vessel distribution in highly scattering biological tissue. The principle of phase-resolved ODT based on digital Hilbert transformation is described and verified by measuring polystyrene solution flow velocity through glass capillary and microchannels of biochip respectively. With measurement for the Doppler frequency shift of the polystyrene flowing through glass capillary, the curve of the velocity of flow is obtained. The obtained images with high spatial and velocity resolutions, demonstrates that the developed ODT system has promising value for future clinical applications.