光散射学报, 2014, 26 (2): 188, 网络出版: 2014-06-30  

光谱法研究ZnO量子点与头孢哌酮钠的相互作用

Study on the Interaction of Cefoperazone Sodium with ZnO Quantum Dots by Spectrometry
作者单位
1 咸阳师范学院化学与化工学院, 咸阳 712000
2 天津力神电池股份有限公司研究院, 天津 300384
摘要
本文采用均匀沉淀法, 在室温条件下, 合成了较为稳定的ZnO量子点。用荧光光谱法、紫外可见分光光度法分析了ZnO量子点与头孢哌酮的相互作用, 用Stern-Volmer 方程研究了头孢哌酮对ZnO量子点的荧光猝灭作用, 结果表明属于静态荧光猝灭, 计算了不同温度时的猝灭常数(292K: 9.550×103 L·mol-1、303K: 5.980×103 L·mol-1、313K: 4.412×103 L·mol-1)和热力学参数, 证明二者主要以范德华作用和氢键作用力结合。根据 Forster 的偶极-偶极非辐射能量转移原理计算出结合位置距离色氨酸残基2.47nm, 发生分子内的非辐射能量转移。为探讨纳米颗粒与此类药物分子之间相互作用的化学机理提供了重要的信息。
Abstract
ZnO quantum dots were synthesized by a precipitation method under the condition of room temperature. The interaction of ZnO quantum dots with the cefoperazone sodium were studied by the fluorescence quenching spectra and ultraviolet visible spectra. Fluorescence quenching of ZnO quantum dots and the cefoperazone sodium were studied by Stern-Volmer equation, which belongs to static fluorescence quenching. The quenching constants (KSV) between ZnO quantum dots and the cefoperazone sodium were (292K:9.550×103 L·mol-1;303K:5.980×103 L·mol-1;313K:4.412×103 L·mol-1), respectively. The latter show that the binding power between them is mainly Fan Wah interaction and hydrogen bonding interaction. Furthermore, the binding distance r= 2.47nm between ZnO quantum dots and the cefoperazone sodium was obtained based on the mechanism of Forsternon-radiation energy transfer.The results are useful for understanding the chemical mechanism of interaction between nanoparticle and this kind of medical molecule.

王欢, 史亚鹏, 陈佑宁. 光谱法研究ZnO量子点与头孢哌酮钠的相互作用[J]. 光散射学报, 2014, 26(2): 188. WANG Huan, SHI Ya-peng, CHEN You-ning. Study on the Interaction of Cefoperazone Sodium with ZnO Quantum Dots by Spectrometry[J]. The Journal of Light Scattering, 2014, 26(2): 188.

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