光学学报, 2007, 27 (11): 2038, 网络出版: 2007-11-12   

组织模型偏振后向散射差分光谱的测量

Measurement of Polarized Backscattering Differential Spectra for Tissue Phantom
作者单位
华中科技大学生命科学与技术学院, 武汉 430074
摘要
建立了一套用于测量生物组织模型偏振后向散射差分光谱的实验系统。在系统中,线偏振光入射到样品表面,检偏器和光谱仪配合记录后向散射光中的平行和垂直分量,随后计算出差分光谱。采用了平均直径分别为5.0 μm、9.0 μm的两种聚乙烯小球悬浮液进行实验,结果与蒙特卡罗模拟进行对照,验证了实验系统的正确性。初步研究了粒子尺寸分布变化对差分光谱的影响,结果表明,偏振散射差分光谱能敏感地反映粒子尺寸分布的变化,在大小粒子的混合液中,大粒子浓度一定程度的增加,光谱仍保留小粒子的振荡趋势,但差分光强减小。该方法对于早期癌症检测具有潜在应用意义。
Abstract
A system for measuring polarized backscattering differential spectrum is reported. In the system, linearly polarized light is used to illuminate the sample surface, parallel and perpendicular components of its backscattered light are measured with polarizer and spectroscope, thereafter, the differential spectrum is calculated. Our system is validated by the comparison with Monte Carlo simulation, in which two kinds of polystyrene spheres with diameters of 5.0 μm and 9.0 μm are used. Based on this, the influence of the distribution of sphere size on differential spectrum is studied initially and roughly. Its result shows the differential spectrum can reflect the change of size distribution sensitively. In the mixtures of small and large spheres, when the relative concentrations of large spheres is increased in limited range, the oscillation frequency keeps identical to the small spheres, but differential signal intensity is weaken . It implies the polarized backscattering differential spectra can be used for pre-cancer detection potentially.

杜玲艳, 邓勇, 鞠栅, 骆清铭, 鲁强. 组织模型偏振后向散射差分光谱的测量[J]. 光学学报, 2007, 27(11): 2038. 杜玲艳, 邓勇, 鞠栅, 骆清铭, 鲁强. Measurement of Polarized Backscattering Differential Spectra for Tissue Phantom[J]. Acta Optica Sinica, 2007, 27(11): 2038.

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