光谱学与光谱分析, 2011, 31 (8): 2215, 网络出版: 2011-08-29
CdTe量子点标记雌二醇衍生物的研究
Study on the Estrogen Derivative Marked by CdTe Quantum Dots
摘要
以巯基乙酸为修饰剂合成高量子产率的CdTe量子点, 并成功标记生物小分子17β-氨基雌二醇。 紫外光谱、 荧光光谱、 红外光谱以及倒置显微镜照片分析表明CdTe量子点在活化剂N-羟基琥珀酰亚胺的作用下, 通过表面的羧基与17β-氨基雌二醇的氨基以共价键结合, 这为建立基于量子点探针的新型的药物筛选模型提供了实验基础。
Abstract
Abstract: Water-soluble CdTe quantum dots (QDs) stabilized by thioglycolic acid (TGA) with high quantum yield were synthesized. And the small biomolecule 17β-amino-estradiol was marked successfully by CdTe QDs. The analysis of UV-Vis spectroscopy, fluorescence spectroscopy, infrared spectroscopy and inverted microscope photographs showed that the surface carboxyl of CdTe quantum dots conjugated with the amino of 17β-amino-estradiol through the activation of N-hydroxysuccinimide. 17β-amino-estradiol marked by CdTe QDs successfully provided an experimental basis for new drug screening model.
钟文英, 张翠, 许国峰, 严明, 许丹科. CdTe量子点标记雌二醇衍生物的研究[J]. 光谱学与光谱分析, 2011, 31(8): 2215. ZHONG Wen-ying, ZHANG Cui, XU Guo-feng, YAN Ming, XU Dan-ke. Study on the Estrogen Derivative Marked by CdTe Quantum Dots[J]. Spectroscopy and Spectral Analysis, 2011, 31(8): 2215.
PDF全文
