中国激光, 2011, 38 (s1): s104004, 网络出版: 2011-11-23
基于功能近红外光谱参数的颅脑创伤实时监测
Monitoring Traumatic Brain Injury by Using Functional Near-Infrared Spectroscopy
医用光学 功能近红外光谱 优化散射系数 脑水肿 颅内压 颅脑创伤 medical optics functionality near infrared spectroscopy reduced scattering coefficient traumatic brain edema intracranial pressure traumatic brain injury
摘要
利用功能近红外光谱技术(fNIRS)监测颅脑创伤(TBI)模型的大鼠脑组织。在大鼠左头部建立急性局灶性脑挫裂伤模型,以功能近红外光谱技术监测并记录颅脑创伤后大鼠脑部组织的优化散射系数,并利用核磁共振影像学、干湿比重法、有创颅内压(ICP)监测技术监测大鼠颅脑创伤后脑水肿和ICP的变化。实验结果显示创伤后脑部组织的优化散射系数、干湿比重法测量的脑水含量(BWC)和创ICP监测仪测量的ICP,三者在颅脑创伤后随时间的变化规律一致,大鼠脑组织的优化散射系数与BWC和ICP均存在正相关,且对颅脑创伤后脑组织的变化更为敏感。这说明优化散射系数是颅脑创伤监测的良好指标参数。
Abstract
Functional near infrared spectroscopy (fNIRS) technology is utilized to monitor brain tissue of rat model of traumatic brain injury (TBI). The reduced scattering coefficient of the local cortex of rats is monitored and recorded in vivo and real time by the fNIRS system. Brain water content (BWC) is measured by the wet and dry weight method. Intracranial pressure (ICP) is measured invasive ICP monitor. Imaging data of rat model is detected by small animal magnetic resonance imaging (MRI). Experimental results show that, there exists positive correlation between parameters and BWC, and ICP, the occurrence and development of cerebral edema can be detected earlier with the sensitive indicator of scattering coefficient.
谢捷如, 钱志余, 邓宁堃, 杨天明, 李韪韬, 胡光霞. 基于功能近红外光谱参数的颅脑创伤实时监测[J]. 中国激光, 2011, 38(s1): s104004. Xie Jieru, Qian Zhiyu, Deng Ningkun, Yang Tianming, Li Weitao, Hu Guangxia. Monitoring Traumatic Brain Injury by Using Functional Near-Infrared Spectroscopy[J]. Chinese Journal of Lasers, 2011, 38(s1): s104004.