激光与光电子学进展, 2012, 49 (2): 020001, 网络出版: 2011-11-28
光生物调节作用研究进展 下载: 529次
Progress in Photobiomodulation Studies
生物技术 光生物调节作用 内稳态 自适应 康复 诊断 biotechnology photobiomodulation homeostasis self-adaptation rehabilitation diagnosis
摘要
激光或单色光的强度可以分为低、中和高三个等级,其生物调节作用称为光生物调节作用。从内稳态的角度综述相应的研究进展。功能内稳态是维持功能充分稳定发挥的负反馈机制,它可以抵抗低于阈值的内外干扰,但被高于阈值的应激所打破。处于内稳态的应激称为成功应激,远离内稳态的应激称为慢性应激。成功应激打破一个功能内稳态之后,能够建立另一个功能内稳态。弱光可以调节慢性应激,但对成功应激或处于功能内稳态的功能无效。细胞的多种膜蛋白可以协同介导低强度单色光的自适应调节。内源性光敏剂介导中强度单色光的调节作用。弱光可以用于诊断功能内稳态或成功应激本身和其形成过程。并讨论了光生物调节作用在外科快速康复中的应用。
Abstract
Photobiomodulation (PBM) is a biomodulation of laser irradiation (LI) or monochromatic light. The LI may be low intensity LI (LIL) at about 10 mW/cm2, moderate intensity LI (MIL) at 0.1~1.0 W/cm2 or high intensity LI. The progress in PBM studies is reviewed from homeostatic viewpoint in this paper. Function-specific homeostasis (FSH) is a negative-feedback response of a biosystem to maintain the function-specific conditions inside the biosystem so that the function is perfectly performed. FSH can resist internal or/and external disturbance under threshold, but can be disrupted by FSH-specific stress (FSS). There is a FSS-specific homeostasis (FSSH) in which a FSS not only disrupts the original FSH, but also establishes a new FSH so that it is called a successful stress. Low level LI (LLL) has been so defined that it cannot modulate a successful stress or a function in its FSH, but it can modulate a FSS far from its FSSH. LIL might be coordinately mediated by many kinds of proteins in membrane of cells or cellular organellae so that the FSH can be self-adaptively established. MIL might be mediated by endogenetic photosensitive proteins. LLL can be used to diagnose the process for a function to establish its FSH or for a FSS to establish its FSSH and the FSH or FSSH itself. The applications of PBM in enhanced recovery after surgery are also discussed.
刘承宜, 蔡庆, Karu Tiina I, 段锐, Wilden Lutz. 光生物调节作用研究进展[J]. 激光与光电子学进展, 2012, 49(2): 020001. Liu Chengyi, Cai Qing, Karu Tiina I, Duan Rui, Wilden Lutz. Progress in Photobiomodulation Studies[J]. Laser & Optoelectronics Progress, 2012, 49(2): 020001.