发光学报, 2012, 33 (11): 1215, 网络出版: 2012-11-13
NaYF4∶Yb3+,Er3+发光上转换纳米晶的表面修饰及其生物效应
Surface Modification of NaYF4∶Yb3+,Er3+ Luminescent Upconversion Nanocrystals and Biological Effects
摘要
不理想的发光上转换纳米晶(UCNPs)表面效应成为其生物标记的主要障碍。本文合成了表面带有氨基功能基团的水溶性NaYF4∶Yb3+, Er3+ UCNPs, 并通过共价偶联的方式将聚乙二醇(PEG)分子修饰到其表面。光谱测试表明纳米晶的发光性质基本没有变化, 扫描电镜结果说明修饰的PEG分子在一定程度上减少了纳米晶的聚集。最后, 细胞毒性实验证明这种修饰后的上转换纳米晶具有良好的生物相容性。
Abstract
Undesirable surface effect of luminescent upconversion nanoparticles (UCNPs) is a major obstacle to the biomarker. In this work, we synthesized the water-soluble NaYF4∶Yb3+, Er3+ UCNPs with amino functional groups and polyethylene glycol (PEG) molecules modified by covalent coupling of the way to the surface of UCNPs. The spectral characterization showed that the luminescent properties of UCNPs unchanged. Scanning electron microscopy results indicate that modification of PEG molecules distinctly reduce the aggregation of UCNPs. The cell toxicity experiments show that this modification on the UCNPs has good biocompatibility.
宋凯, 杜创, 赵军伟, 孔祥贵. NaYF4∶Yb3+,Er3+发光上转换纳米晶的表面修饰及其生物效应[J]. 发光学报, 2012, 33(11): 1215. SONG Kai, DU Chuang, ZHAO Jun-wei, KONG Xiang-gui. Surface Modification of NaYF4∶Yb3+,Er3+ Luminescent Upconversion Nanocrystals and Biological Effects[J]. Chinese Journal of Luminescence, 2012, 33(11): 1215.