光学学报, 2013, 33 (8): 0817001, 网络出版: 2013-07-09
光学相干层析成像对牙釉质矿密度的定量测量
Measurement of Enamel Mineral Density by Optical Coherence Tomography
生物光学 矿物质密度 光学相干层析 牙釉质 羟基磷灰石 光衰减系数 biotechnology mineral density optical coherence tomography enamel hydroxyapatite optical attenuation coefficient
摘要
将光学相干层析(OCT)成像技术应用于牙釉质矿物质密度(MD)的定量测量。该测量是基于骨组织的OCT光衰减系数(OAC)与MD的线性关系来实现的。用OCT扫描密度范围为1.28~1.9 g/cm3的羟基磷灰石（牙釉质主要成分），从OCT图拟合出它们各自的OAC, 并绘制OAC与MD直线作为校准直线；用OCT扫描牙釉质并从图中拟合出牙釉质的OAC；从校准直线中获取对应的MD。测量结果显示：正常牙釉质的MD范围为2.5~3.1 g/cm3，此值与相关文献结果相符；而龋齿牙釉质的MD都比较小，约为2.0 g/cm3。实验表明OCT是一种高灵敏度的无损成像技术，在早期龋牙的定量研究和临床诊断方面具有潜在的应用前景。
Abstract
The measurement on the mineral density (MD) of human tooth enamel with optical coherence tomography (OCT) is done, which is based on the linear relationship between the optical attenuation coefficient (OAC) and MD. Synthetic calcium hydroxyapatite discs (the key component of enamel) with different densities ranging from 1.28 g/cm3 to 1.9 g/cm3 are scanned with OCT, OACs are fitted from OCT images, and MD versus OAC curve as a calibration curve is developed; then the OACs within OCT images of human teeth are obtained; the MD is determined according to the calibration curve of OAC and MD. The MD of sound enamel is found to be 2.5~3.1 g/cm3, which is in agreement with literature values; while the MD of white spot lesions is around 2.0 g/cm3. This non-destructive method has the potential to be used in quantitative determination of demineralization and remineralization of enamel and clinic.
李江华, 黄海, 唐志列, 刘颂豪. 光学相干层析成像对牙釉质矿密度的定量测量[J]. 光学学报, 2013, 33(8): 0817001. Li Jianghua, Huang Hai, Tang Zhilie, Liu Songhao. Measurement of Enamel Mineral Density by Optical Coherence Tomography[J]. Acta Optica Sinica, 2013, 33(8): 0817001.
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