以3, 5-二氟溴苯为原料, 3, 5-二氟溴苯和2-甲基-3-丁炔-2-醇在四(三苯基膦)钯催化下合成4-(3, 5-二氟苯)2-甲基-3-丁炔-2-醇。4-(3, 5-二氟苯)2-甲基-3-丁炔-2-醇在KOH作用下生成3, 5-二氟苯乙炔。3, 5-二氟苯乙炔与碘代苯发生Sonogashira反应, 合成出3, 5-二氟二苯乙炔中间体, 经烷基化反应合成出6种含氟炔类液晶。进行了产品结构标定以及参数的测定, 确定了化合物有较大的光学各向异性(Δn), 较宽的相变温度范围。

4-(3,5-difluorophenyl)-2-methylbut-3-yn-2-ol is prepared with 3,5-difluorobromobenzene and 2-methyl-3-butyn-2-ol by the catalyzed of Tetrakis(triphenylphosphine)palladium. 3,5-difluorophenylacetylene is synthesized with 4-(3,5-difluorophenyl)-2-methylbut-3-yn-2-ol and potassium hydroxide in paraffin oil. Six fluoro-phenytolene compounds of liquid crystal were prepared by the alkyation of 3,5-difluorotolanes intermediates which were synthesized by the sonogashira reaction.These compounds not only have large optical anisotropy(Δn), but also have wider nematic phase temperature range by a series photoelectricity test and DSC analysis. These material can be used in TN,STN and TFT displays.