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纳米金提高光敏剂单态氧产率的研究

Enhanced Singlet Oxygen Yield of Photosensitizer by Gold Nanoparticles

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摘要

光动力疗法是效果很好的癌症微创治疗方法, 主要依靠光敏性药物(也称为光敏剂)进行癌细胞杀伤。在光动力治疗中, 光敏剂单态氧产率是影响光动力效果的关键因素。利用纳米金的光学特性来提高光敏剂的单态氧产率为研制新型光敏剂来改进光动力治疗方法提供了一种新的途径。利用绿光LED灯、红光LED灯、氙灯和635 nm连续激光四种光源对混合有光敏剂原卟啉Ⅸ和纳米金的溶液进行光照。用单态氧检测试剂测定了光照后的单态氧产率。

Abstract

Photodynamic therapy, a minimally invasive cancer treatment modality, has proven to have low morbidity and good tolerance. It includes the administration of a photosensitive drug and subsequent irradiation with appropriate light to produce singlet oxygen for the destruction of cells. At present, researchers have carried out a lot of work to improve the efficacy of photosensitizer on photodynamic therapy. Biocompatible gold nanoparticles that exhibit surface-plasmon resonance have been used as drug-delivery carriers or tools for tumor detection.

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中图分类号:R318.51

DOI:10.3969/j.issn.1007-7146.2012.05.001

所属栏目:基础研究

基金项目:国家自然科学基金项目(60927011, 61120106013, 11274249)

收稿日期:2012-09-02

修改稿日期:2012-10-02

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作者单位    点击查看

沈利剑:生物医学信息工程教育部重点实验室, 西安交通大学生命科学与技术学院, 陕西 西安 710049
许皓:生物医学信息工程教育部重点实验室, 西安交通大学生命科学与技术学院, 陕西 西安 710049
王斯佳:生物医学信息工程教育部重点实验室, 西安交通大学生命科学与技术学院, 陕西 西安 710049
张镇西:生物医学信息工程教育部重点实验室, 西安交通大学生命科学与技术学院, 陕西 西安 710049

联系人作者:沈利剑(xmb977@xjtu.edu.cn)

备注:沈利剑(1979-), 男, 陕西西安人, 学士, 主要从事生物医学工程方面研究。

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【9】屈晓超.纳米金颗粒标记肿瘤细胞的双光子激发显微成像及其光热效应对细胞的影响[D]. 西安: 西安交通大学, 2008.
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引用该论文

SHEN Lijian,XU Hao,WANG Sijia,ZHANG Zhenxi. Enhanced Singlet Oxygen Yield of Photosensitizer by Gold Nanoparticles[J]. Acta Laser Biology Sinica, 2012, 21(5): 385-388

沈利剑,许皓,王斯佳,张镇西. 纳米金提高光敏剂单态氧产率的研究[J]. 激光生物学报, 2012, 21(5): 385-388

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