姜黄素具有良好的抗癌活性, 但其水溶性差、中性与碱性pH条件下稳定性不足等因素限制其医学应用。另外, 聚前药两亲分子(polyprodrug amphiphiles)具有载药量高、水溶性改善、纳米结构调控等优势, 在抗肿瘤研究中越来越突显优势。本工作通过缩聚方法成功制备了一种姜黄素的聚前药两亲分子, Poly(Cur-alt-TEG), 具有高载药量, 提高了姜黄素的水溶性和稳定性, 进一步的细胞毒性实验表明其具有良好的抗肿瘤活性。

Curcumin has good anticancer potency, but its poor water solubility and limited stability at neutral and alkaline milieu restricted its medical application. In addition, polyprodrug amphiphiles possess the feature of high drug loading, improved water dispersibility, and advantages for nanostructural fabrication. In the current work, novel curcumin-based polyprodrug amphiphiles, Poly(Cur-alt-TEG), were fabricated by condensation polymerization, possessing high drug loading content, good water solubility, stability. Further cellular experiments revealed that the anticancer effect of Poly(Cur-alt-TEG) was effective.