本文利用CS与TPP的交联作用包覆QT制备CS-QT-TPP纳米颗粒,并以动态光散射研究QT浓度、CS分子量及CS/TPP重量比对所得纳米颗粒粒径与Zeta电位的影响。结果表明,QT浓度由0.15 mg/mL升至0.45 mg/mL时粒径增大,而继续升至0.75 mg/mL时粒径稍微减小;CS分子量越高,粒径越小;而CS/TPP重量比对粒径则无明显影响。CS-QT-TPP纳米颗粒粒径介于711~759 nm之间。CS分子量较低时表面电位较小,而QT浓度与CS/TPP重量比则对Zeta电位无明显影响,CS-QT-TPP纳米颗粒表面均带正电,介于25.7~39.8 mV之间。因此,QT浓度为0.75 mg/mL、CS高分子量为380 kDa及CS/TPP重量比为3/1时制备CS-QT-TPP纳米颗粒最佳。

CS-QT-TPP nano-particle is prepared by the crosslinking effect between CS and TPP and the effect of QT concentration,CS molecular weight and CS/TPP mass ratio on size and Zeta potential are studied by dynamic light scattering.The results show that,CS-QT-TPP nano-particle size increased as QT concentration changed from 0.15 mL to 0.45mg/mL and slightly decreased as the concentration increased to 0.75 mg/mL continuously.CS-QT-TPP nano-particle size decreased as CS molecular weight increased and it was insignificantly affected by CS/TPP mass ratio,it changed in a range of 711~759 nm.Zeta potential of CS-QT-TPP nano-particle decreased as CS molecular decreased and was insignificantly affected by QT concentration,also as CT/TPP mass ratio changed.All CS-QT-TPP nano-particle showed positive Zeta potential(25.7~39.8 mV).The best conditions for preparing CS-QT-TPP nano-particle are QT concentration of 0.75 mg/mL,CS molecular weight of 380 kDa and CS/TPP mass ratio of 3/1.