为了抑制激光成像中的散斑噪声，采用灰度共生矩阵构建了激光显微散斑分析评价系统。系统采用波长为405nm的激光作为显微系统光源，利用电压驱动音圈电机振动样品对激光散斑噪声大小进行控制，同时采用CCD图像传感器采集不同驱动电压下的激光散斑噪声。通过对散斑噪声的角二阶矩、对比度、熵和逆差距特征参量的分析，较好地表征了激光散斑噪声的变化。结果表明，灰度共生矩阵方法可对激光显微成像中的散斑进行评价。

In order to suppress speckle noise in laser imaging, a laser microscopic speckle analysis and evaluation system was built by using the gray level co-occurrence matrix. In this system, a 405nm wavelength laser was used as light source of the microscopic system and the vibration of an sample driven by a voice coil motor through voltage was used to control the size of laser speckle noise. At the same time, a CCD image sensor was used to collect laser speckle noise under different driving voltages. Through analyzing the characteristic parameters such as angular second moment, contrast, entropy and inverse difference moment of laser speckle noise, the characteristics of laser speckle noise were appropriately characterized. The results show that the gray level co-occurrence matrix method can be used to evaluate the speckle in laser microscopic imaging.