激光生物学报, 2016, 25 (2): 117, 网络出版: 2016-07-26  

光学成像中兼具光学和力学性质的生物组织仿体

Tissue Phantoms with Optical and Mechanical Properties In Optical Imaging
作者单位
1 北京理工大学生命学院, 北京100081
2 融合医工系统与健康工程工业和信息化部重点实验室, 北京理工大学, 北京 100081
摘要
在生物医学光学成像方法的研发、评估和使用中, 需要用到在较长时间内具有稳定的光学及力学属性的生物组织仿体, 以使光学成像实验可以重复进行。这些仿体一般由混有散射、吸收粒子的基质制成。常用散射粒子包括脂质微粒、聚合物微球、金属氧化物粉末和金纳米粒子等, 吸收粒子(及其溶液)包括血液、印度墨水(Indian Ink)和分子染料等。常用来模拟组织特性的基质包括硅胶、纤维蛋白和聚乙烯醇凝胶(Polyvinyl alcohol cryogel, PVA-C)等。讨论和分析常见仿体的光学性质(吸收系数、散射系数、折射率)和力学性质(弹性和粘弹性)。从生物相容性、制备难易程度及耗时情况、稳定性等方面比较了几种常见散射粒子、吸收粒子和基质的优缺点, 并据此总结其适用范围。最后对仿体研究的发展进行了展望。
Abstract
In the development, evaluation and usage of biomedical optical imaging method a biomedical tissue phantom with stable optical and mechanical parameters during a long period of time is needed, so that the optical imaging experiments can be repeated. Those phantoms are made by certain substance mixed with some certain scattering particles and absorbing particles. Common scattering particles include lipids, polymer, micro-spheres, metal oxides, gold nano-particles etc., while absorbing particles(and its solution) include blood, Indian ink, molecular dyes etc. The common substances to simulate characteristics of tissue include silicone, fibrin and Poly(vinyl alcohol) cryogel (PVA-C) etc. The state of art durable tissue phantoms are reviewed and analyzed in optical properties involving absorbing index, scattering index and refractive index as well as medical properties involving elasticity and viscoelasticity. The advantages, disadvantages in biocompatibility, difficulty in preparation and time consumed and durability are compared. And its scope is summarized depending on the characteristics of the tissue phantoms. At last, the development of the phantoms is discussed.

岳华洋, 高天欣, 刘万年, 唐晓英. 光学成像中兼具光学和力学性质的生物组织仿体[J]. 激光生物学报, 2016, 25(2): 117. YUE Huayang, GAO Tianxin, LIU Wannian, TANG Xiaoying. Tissue Phantoms with Optical and Mechanical Properties In Optical Imaging[J]. Acta Laser Biology Sinica, 2016, 25(2): 117.

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