首页 > 论文 > 激光与光电子学进展 > 54卷 > 6期(pp:60005--1)

视网膜血氧饱和度测量技术综述

Review for Retinal Oxygen Saturation Measurement Technology

  • 摘要
  • 论文信息
  • 参考文献
  • 被引情况
  • PDF全文
分享:

摘要

视网膜血氧测量技术可以为医学诊断提供可靠的视网膜血氧新陈代谢信息,这些信息可以反映出全身微循环状态。基于光谱法的非侵入性的视网膜血氧饱和度测量是生命科学研究的新热点,国外已开展了大量的研究工作,国内的相关研究还处于起步阶段。为更好地促进视网膜血氧测量在生命科学领域中的研究和应用,对现有的研究成果进行了梳理和回顾。首先介绍了视网膜血氧测量的基本原理,概述了当前已有的视网膜血氧测量技术并讨论了各自的优缺点;然后对现有研究成果和应用情况进行总结,并对视网膜血氧测量存在的若干问题进行讨论;最后对其在生命科学中的研究和发展进行了预测和展望。

Abstract

Retinal blood oxygen measurement technology can provide reliable retinal blood oxygen metabolism information for medical diagnosis, which can stand for systemic microcirculation status. The noninvasive measurement of retinal oxygen saturation (SO2) is based on spectroscopy, which is a hot point for researchers in the field of life science. While researchers overseas have done a lot of work, researchers in China are still at the threshold of this field. Existed theses are reviewed to promote research and application in this regard. We firstly introduce the basic principle of retinal oximetry, and then summarize the various techniques that have been applied to the retinal oximetry. Advantages and limitations of each are discussed. The research achievement and application situation in retinal diseases using retinal oximetry are also summarized, and major problems of retinal oximetry encountered are discussed. Lastly, future perspectives of the retinal oximetry used in life science are discussed.

投稿润色
补充资料

中图分类号:TH744

DOI:10.3788/lop54.060005

所属栏目:综述

基金项目:国家重大科学仪器设备开发专项资助项目(2013YQ49085903)

收稿日期:2016-12-21

修改稿日期:2017-02-18

网络出版日期:--

作者单位    点击查看

先永利:中国科学院自适应光学重点实验室, 四川 成都 610209电子科技大学光电信息学院, 四川 成都 610054中国科学院光电技术研究所, 四川 成都 610209中国科学院大学, 北京 100049
戴 云:中国科学院自适应光学重点实验室, 四川 成都 610209中国科学院光电技术研究所, 四川 成都 610209
高椿明:电子科技大学光电信息学院, 四川 成都 610054

联系人作者:先永利(xyl123@mail.ustc.edu.cn)

备注:先永利(1986-),女,博士研究生,主要从事生物医学光学、图像处理方面的研究。

【1】Hardarson S H, Stefansson E. Retinal oxygen saturation is altered in diabetic retinopathy[J]. British Journal of Ophthalmology, 2012, 96(4): 560-563.

【2】Hammer M, Heller T, Jentsch J, et al. Retinal vessel oxygen saturation under flicker light stimulation in patients with nonproliferative diabetic retinopathy[J]. Investigative Ophthalmology & Visual Science, 2012, 53(7): 4063-4068.

【3】Hardarson S H, Gottfredsdottir M S, Halldorsson G H, et al. Glaucoma filtration surgery and retinal oxygen saturation[J]. Investigative Ophthalmology & Visual Science, 2009, 50(11): 5247-5250.

【4】Vandewalle E, Pinto L A, Olafsdottir O B, et al. Phenylephrine 5% added to tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients[J]. Acta Ophthalmologica, 2013, 91(8): 733-737.

【5】Olafsdottir O B, Hardarson S H, Gottfredsdottir M S, et al. Retinal oximetry in primary open-angle glaucoma[J]. Investigative Ophthalmology & Visual Science, 2011, 52(9): 6409-6413.

【6】Hardarson S H, Stefansson E. Oxygen saturation in central retinal vein occlusion[J]. American Journal of Ophthalmology, 2010, 150(6): 871-875.

【7】Hardarson S H, Elfarsson A, Agnarsson A B, et al. Retinal oximetry in central retinal artery occlusion[J]. Acta Ophthalmologica, 2013, 91(2): 189-190.

【8】Hardarson S H. Retinal oximetry[D]. Reykjavík: University of Iceland, 2013: 1-7.

【9】Tsacopoulos M, Lehmenkuhler A. A double-barrelled Pt-microelectrode for simultaneous measurement of PO2 and bioelectrical activity in excitable tissues[J]. Experientia, 1977, 33(10): 1337-1338.

【10】Wilson D F, Vanderkooi J M, Green T J, et al. A versatile and sensitive method for measuring oxygen[J]. Advances in Experimental Medicine & Biology, 1987, 215: 71-77.

【11】Hickham J B, Frayser R, Ross J C. A study of retinal venous blood oxygen saturation in human subjects by photographic means[J]. Circulation, 1963, 27(3): 375-385.

【12】Wang Ling. Optical coherence tomography for retinal imaging[D]. Hangzhou: Zhejiang University, 2008: 106.
王 玲. 光学相干层析视网膜成像系统研究[D]. 杭州: 浙江大学, 2008: 106.

【13】Hardarson S H, Harris A, Karlsson R A, et al. Automatic retinal oximetry[J]. Investigative Ophthalmology & Visual Science, 2006, 47(11): 5011-5016.

【14】Harris A, Dinn R B, Kagemann L, et al. A review of methods for human retinal oximetry[J]. Ophthalmic Surgery Lasers & Imaging, 2003, 34(2): 152-164.

【15】史国华, 李 昊, 卢 婧, 等. 一种测量眼底视网膜血氧饱和度的装置及方法: 中国, CN201010617782. 5[P]. 2011-04-27.

【16】戴 云, 先永利, 杜 睿, 等. 基于眼底相机的双波长视网膜血管血氧测量系统: 中国, CN201510496619. 0[P]. 2015-08-14.

【17】Cohen A J, Laing R A. Multiple scattering analysis of retinal blood oximetry[J]. IEEE Transactions on Biomedical Engineering, 1976, 23(5): 391-400.

【18】Delori F C. Noninvasive technique for oximetry of blood in retinal vessels[J]. Applied Optics, 1988, 27(6): 1113-1125.

【19】Tiedeman J S, Kirk S E, Srinivas S, et al. Retinal oxygen consumption during hyperglycemia in patients with diabetes without retinopathy[J]. Ophthalmology, 1998, 105(5): 31-36.

【20】Beach J M, Schwenzer K J, Srinivas S, et al. Oximetry of retinal vessels by dual-wavelength imaging: calibration and influence of pigmentation[J]. Journal of Applied Physiology, 1999, 86(2): 748-758.

【21】Schweitzer D, Hammer M, Kraft J, et al. In vivo measurement of the oxygen saturation of retinal vessels in healthy volunteers[J]. IEEE Transactions on Biomedical Engineering, 1999, 46(12): 1454-1465.

【22】Khoobehi B, Beach J M, Kawano H. Hyperspectral imaging for measurement of oxygen saturation in the optic nerve head[J]. Investigative Ophthalmology & Visual Science, 2004, 45(5): 1464-1472.

【23】Khoobehi B, Ning J, Puissegur E, et al. Retinal oxygen saturation evaluation by multi-spectral fundus imaging[C]. SPIE, 2007, 6511: 65110B.

【24】Hardarson S H, Harris A, Karlsson R A, et al. Automatic retinal oximetry[J]. Investigative Ophthalmology & Visual Science, 2006, 47(11): 5011-5016.

【25】Hammer M, Vilser W, Riemer T, et al. Retinal vessel oximetry-calibration, compensation for vessel diameter and fundus pigmentation, and reproducibility[J]. Journal of Biomedic Optics, 2008, 13(5): 054015.

【26】Kim S K, Kim D M, Suh M H, et al. Retinal oximetry based on nonsimultaneous image acquisition using a conventional fundus camera[J]. IEEE Transactions on Medical Imaging, 2011, 30(8): 1577-1580.

【27】Geirsdottir A, Palsson O, Hardarson S, et al. Retinal vessel oxygen saturation in healthy individuals[J]. Investigative Ophthalmology & Visual Science, 2012, 53(9): 5433-5442.

【28】Xian Yongli, Dai Yun, Gao Chunming, et al. Dual-wavelength retinal oximeter[J]. Opto-Electronic Engineering, 2016, 43(6): 68-74.
先永利, 戴 云, 高椿明, 等. 双波长视网膜血氧测量系统[J]. 光电工程, 2016, 43(6): 68-74.

【29】Smith M H, Denninghoff K R, Hillman L W, et al. Oxygen saturation measurements of blood in retinal vessels during blood loss[J]. Journal of Biomedical Optics, 1998, 3(3): 296-303.

【30】Lompado A. A confocal scanning laser ophthalmoscope for retinal vessel oximetry[D]. Huntsville: University of Alabama, 1999: 56-60.

【31】Smith M H, Denninghoff K R, Lompado A, et al. Retinal vessel oximetry: toward absolute calibration[C]. SPIE, 2000, 3908: 217-226.

【32】Manivannan A, Sharp P F, Rasta S H. Spectroscopic imaging of the retinal vessels using a new dual-wavelength[C]. SPIE, 2009, 7368: 736805.

【33】Li H, Lu J, Shi G H, et al. Measurement of oxygen saturation in small retinal vessels with adaptive optics confocal scanning laser ophthalmoscope[J]. Journal of Biomedical Optics, 2011, 16(11): 110504.

【34】Rasta S H, Manivannan A, Sharp P F. Spectral imaging technique for retinal perfusion detection using confocal scanning laser ophthalmoscopy[J]. Journal of Biomedical Optics, 2012, 17(11): 116005.

【35】Kagemann L, Wollstein G, Wojtkowski M, et al. Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography[J]. Journal of Biomedical Optics, 2007, 12(4): 041212.

【36】Liu X, Kang J U. Depth-resolved blood oxygen saturation assessment using spectroscopic common-path Fourier domain optical coherence tomography[J]. IEEE Transactions on Biomedical Engineering, 2010, 57(10): 2572-2575.

【37】Liu W Z, Jiao S L, Zhang H F. Accuracy of retinal oximetry: a Monte Carlo investigation[J]. Journal of Biomedical Optics, 2013, 18(6): 066003.

【38】Chen S Y, Yi J, Zhang H F. Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography[J]. Biomedical Optics Express, 2015, 6(8): 2840-2853.

【39】Nakamura D, Matsuoka N, Tatsuguchi K, et al. Oxygen saturation imaging of human retinal vessels and measurement in eye disease patient for clinical application[C]. SPIE, 2010, 7550(1): 75501x.

【40】Chen Jie, Jian Wenyuan , Duan Junguo. Research and application of retinal oxygen saturation measurement technology[J]. Med J West China, 2013, 25(11): 1740-1744.
陈 洁, 蹇文渊, 段俊国. 视网膜血氧饱和度测定技术研究及应用进展[J]. 西部医学, 2013, 25(11): 1740-1744.

【41】Ji Lu. The research of correlation between diabetic retinal vascular caliber with TCM symptoms[D]. Chengdu: ChengDu University of TCM, 2015.
冀 璐. 2型糖尿病视网膜血管管径与中医证候相关性研究[D]. 成都: 成都中医药大学, 2015.

【42】Du Shaolin, Wang Jiya, Ju Lanli, et al. Relationship between visual field measurements and retinal oxygen saturation in suspected glaucoma patients[J]. Journal of Clinical Ophthalmology, 2015, 23(3): 210-212.
杜绍林, 王继亚, 鞠兰丽, 等. 可疑青光眼患者视野指数与眼底血管变化的关系[J]. 临床眼科杂志, 2015, 23(3): 210-212.

【43】Lin L L, Dong Y M, Zong Y, et al. Study of retinal vessel oxygen saturation in ischemic and non-ischemic branch retinal vein occlusion[J]. International Journal of Ophthalmology, 2016, 9(1): 99-107.

【44】Li Jing, Ma Jianming, Wang Ningli. Application of retinal oximeter in ophthalmology[J]. Chin J Ophthalmol, 2015, 51(11): 864-868.
李 静, 马建明, 王宁利. 视网膜血氧测定仪在眼科的应用进展[J]. 中华眼科杂志, 2015, 51(11): 864-868.

【45】Yang Jingyan, You Bing, Wang Qian, et al. Retinal vessel oxygen saturation in Chinese healthy individuals[J]. Ophtalmol CHN, 2016, 25(5): 339-342.
杨婧研, 由 冰, 王 倩, 等. 正常人群视网膜血氧饱和度的测量[J]. 眼科, 2016, 25(5): 339-342.

【46】Yue Yi, Zhang Xiaomin, Wang Meiyan, et al. The oxygen saturation and retinal blood vessel diameter in patients with convalescence Vogt-Koyanagi-Harada syndrome[J]. Chin J Ocul Fundus Dis, 2015, 31(6): 545-548.
乐 毅, 张晓敏, 王梅艳, 等. Vogt-Koyanagi-Harada综合征恢复期患者视网膜血管血氧饱和度与血管直径测量[J]. 中华眼科杂志, 2015, 31(6): 545-548.

【47】Ling Ning, Zhang Yudong, Rao Xuejun, et al. A small adaptive optical imaging system for cells of living human retina[J]. Acta Optica Sinica, 2004, 24(9): 1153-1158.
凌 宁, 张雨东, 饶学军, 等. 用于活体人眼视网膜观察的自适应光学成像系统[J]. 光学学报, 2004, 24(9): 1153-1158.

【48】Xiao Fei, Dai Yun, Zhao Junlei, et al. High-resolution retinal imaging system with dual deformable mirrors[J]. Acta Optica Sinica, 2015, 35(5): 0501004.
肖 飞, 戴 云, 赵军磊, 等. 双变形镜人眼视网膜高分辨率显微成像系统[J]. 光学学报, 2015, 35(5): 0501004.

【49】Kang Jian, Dai Yun, Liang Bo, et al. Binocular higher-order aberration correction and vision analysis system[J]. Acta Optica Sinica, 2015, 35(10): 1033001.
康 健, 戴 云, 梁 波, 等. 双眼高阶像差校正与视觉分析系统[J]. 光学学报, 2015, 35(10): 1033001.

【50】Yang Yanrong, Dai Yun. Evaluation of the effect on eye aberration on retinal imaging quality based on the root mean square error and correlation coefficient[J]. Acta Optica Sinica, 2017, 37(3): 0333001.
杨彦荣, 戴 云. 基于均方根误差和相关系数评价人眼像差对视网膜像质的影响[J]. 光学学报, 2017, 37(3): 0333001.

【51】Chen S, Yi J, Liu W Z, et al. Monte Carlo investigation of optical coherence tomography retinal oximetry[J]. IEEE Transactions on Biomedical Engineering, 2015, 62(9): 2308-2315.

【52】Li Hao. Image processing and measurement of oxygen saturation with adaptive optics confocal scanning laser ophthalmoscope[D]. Beijing: University of Chinese Academy of Sciences, 2012.
李 昊. AOSLO的视网膜图像处理及在体血氧饱和度测量技术研究[D]. 北京: 中国科学院大学, 2012.

【53】Hardarson S H, Stefansson E. Oxygen saturation in branch retinal vein occlusion[J]. Acta Ophthalmologica, 2012, 90(5): 466-470.

【54】Guduru A, Martz T G, Waters A, et al. Oxygen saturation of retinal vessels in all stages of diabetic retinopathy and correlation to ultra-wide field fluorescein angiography[J]. Investigative Ophthalmology & Visual Science, 2016, 57(13): 5278-5284.

【55】Cheng C S, Lee Y F, Ong C. Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes[J]. Clinical Ophthalmology, 2016, 19(10): 1315-1321.

【56】Zong Y, Lin L, Yi C, et al. Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa at various ages[J]. Graefe′s Archive for Clinical and Experimental Ophthalmology, 2016, 254(2): 243-252.

【57】Eysteinsson T, Hardarson S H, Bragason D, et al. Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa[J]. Acta Ophthalmologica, 2014, 92(5): 449-453.

【58】Ueda-Consolvo T, Fuchizawa C, Otsuka M, et al. Analysis of retinal vessels in eyes with retinitis pigmentosa by retinal oximeter[J]. Acta Ophthalmologica, 2015, 93(6): e446-e450.

【59】Drewes J J. Four-wavelength retinal vessel oximetry[D]. Huntsville: University of Alabama, 1999: 58-88.

【60】Ramella-Roman J C, Mathews S A, Kandimalla H, et al. Measurement of oxygen saturation in the retina with a spectroscopic sensitive multiaperture camera[J]. Optics Express, 2008, 16(9): 6170-6182.

【61】Nabili A, Bardakci D, Helling K, et al. Calibration of an eye oximeter with a dynamic eye phantom[C]. SPIE, 2008, 6870: 68700N.

【62】Lemaillet P, Ramella-Roman J C. Dynamic eye phantom for retinal oximetry measurements[J]. Journal of Biomedical Optics, 2009, 14(6): 064008.

【63】Rodriguez D A, Pfefer T J, Wang Q, et al. A Monte Carlo analysis of error associated with two-wavelength algorithms for retinal oximetry[J]. Investigative Ophthalmology & Visual Science, 2016, 57(14): 6474-6481.

【64】Thamm E, Schweitzer D, Hammer M. A data reduction scheme for improving the accuracy of oxygen saturation calculations from spectrometric in vivo measurements[J]. Physics in Medicine & Biology, 1998, 43(6): 1401-1411.

【65】Halldorsson G H, Benediktson J A, Zoega G M, et al. Automatic registration of spectrophotometric retinal images[J]. Signal Processing Symposium, 2004, 28(5): 5-8.

【66】Xian Yongli, Dai Yun, Gao Chunming, et al. Dual-wavelength retinal image registration based on vessel segmentation and optic disc detection[C]. SPIE, 2016, 9684: 968417.

引用该论文

Xian Yongli,Dai Yun,Gao Chunming. Review for Retinal Oxygen Saturation Measurement Technology[J]. Laser & Optoelectronics Progress, 2017, 54(6): 060005

先永利,戴 云,高椿明. 视网膜血氧饱和度测量技术综述[J]. 激光与光电子学进展, 2017, 54(6): 060005

您的浏览器不支持PDF插件,请使用最新的(Chrome/Fire Fox等)浏览器.或者您还可以点击此处下载该论文PDF