Chinese Optics Letters, 2017, 15 (9): 092301, Published Online: Jul. 19, 2018  

Detection of low-concentration EGFR with a highly sensitive optofluidic resonator Download: 645次

Author Affiliations
1 State Key Laboratory of Advanced Optical Communication Systems and Networks, Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China
2 Shanghai Key Laboratory of Crime Science Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai 200083, China
Abstract
A hollow-core metal-cladding waveguide (HCMW) optofluidic resonator that works based on a free-space coupling technique is designed. An HCMW can excite ultra-high-order modes (UOMs) at the coupled angle, which can be used as an optofluidic resonator to detect alterations of the epidermal growth factor receptor (EGFR) concentration. Theoretical analysis shows that the UOMs excited in the HCMW have a highly sensitive response to the refractive index (RI) variation of the guiding layer. An EGFR solution with a 0.2 ng/mL alteration is detected, and the RI variation caused by the concentration alteration is about 2.5×10 3.

Jianfeng Shang, Hailang Dai, Yun Zou, Xianfeng Chen. Detection of low-concentration EGFR with a highly sensitive optofluidic resonator[J]. Chinese Optics Letters, 2017, 15(9): 092301.

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