随着人类平均寿命的延长, 恶性肿瘤的发病率日趋增高, 严重影响了人们的生存质量, 并给患者及其家庭带来巨大的物质和精神损失。因此, 不断寻求新型有效的肿瘤治疗方式显得愈加重要。高通量低功率激光照射(high fluence low power laser irradiation, HF-LPLI)可通过促使细胞色素C释放到胞质中诱发肿瘤细胞凋亡, 凋亡的肿瘤细胞进一步激活树突状细胞(dendritic cells, DC)。DC是目前已知抗原呈递能力最强的细胞, 活化后的DC可起始机体特异性免疫应答, 使机体产生抗肿瘤免疫效应。本研究的意义在于探究了HF-LPLI在杀伤肿瘤细胞的过程中具有的免疫调节作用。

With the extension of the average life expectancy of human beings, the incidence of malignant tumors is increasing, which seriously affects people’s quality of life and brings great material and mental loss to patients and their families. Therefore, the constant search for new and effective treatment of cancer is even more important. High-throughput low-power laser irradiation can promote the apoptosis of tumor cells by promoting the release of cytochrome C into the cytoplasm. Apoptosis of tumor cells further activates dendritic cells (DCs) that are the most potent antigen-presenting cells. The activated DCs initiate the adaptive immune response and the anti-tumor immune effect. The significance of this research is to explore the immune modulation effects of HF-LPLI in the process of killing tumor cells.