Photonics Research, 2018, 6 (6): 06000530, Published Online: Jul. 2, 2018
Wide-field in situ multiplexed Raman imaging with superresolution
Abstract
Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface-enhanced Raman scattering (SERS) technique, wide-field Raman imaging is developed with a significant improvement in spatial resolution. As a result of the relatively narrow Raman characteristic peaks, optically encoded SERS nanoparticles can be used to perform multiplexed imaging. The results show excellent superresolution wide-field multiplexed imaging performance. The developed technique has extraordinary potential for applications in biological imaging and other related fields.
Houkai Chen, Xiaojing Wu, Yuquan Zhang, Yong Yang, Changjun Min, Siwei Zhu, Xiaocong Yuan, Qiaoliang Bao, Jing Bu. Wide-field in situ multiplexed Raman imaging with superresolution[J]. Photonics Research, 2018, 6(6): 06000530.