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面向血管内脂质斑块检测的超声-OCT成像系统

IVUS-OCT Imaging System for Detection of Intravascular Lipid Plaque

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摘要

血管内超声(IVUS)和血管内光学相干层析(OCT)成像均属无损医学成像技术,常用于人体冠状动脉中薄纤维帽脂质斑块(TCFA)的检查。其中IVUS的探测深度大,能够较为精确地测定TCFA的脂质核心大小,但由于分辨率较低,无法测量TCFA的纤维帽厚度;而OCT分辨率很高,可以精确测量TCFA的纤维帽厚度,但探测深度浅,无法描述脂质核心的全貌。IVUS与血管内OCT相结合,一次检查即可同时获得血管内壁的超声与OCT图像,实现对血管内血栓与斑块的精准诊断。通过设计IVUS和OCT微型集成探头及近端驱动,实现了一套可同时对血管内壁进行IVUS和OCT成像的系统,对血管组织检测深度达到8 mm,横向分辨率优于1 mm,轴向分辨率优于400 μm,同时在1 mm范围内横向分辨率优于10 μm,轴向分辨率优于8 mm。对琼脂和铁丝等搭建的血管模型样品进行了成像实验,验证了系统的可行性。

Abstract

The intravascular ultrasound (IVUS) and the intravascular optical coherence tomography (OCT) both belong to the non-invasive medical imaging techniques, which are often used for the examination of thin cap fibroatheromas (TCFA) in the human coronary arteries. The detection depth of IVUS is large, so the size of TCFA can be measured accurately, but due to the lower resolution, the fiber cap thickness of TCFA cannot be measured, whereas the OCT has high resolution, which enables it to accurately measure the thickness of the TCFA, but it cannot describe the size of TCFA because of small detection depth. By combining IVUS with OCT, ultrasound and OCT tomographic images of the vascular wall can be obtained simultaneously in a single examination, and the accurate diagnosis of intravascular thrombosis and plaque is achieved. In this paper, we design and realize IVUS and OCT integrated micro-scanning probe and near-end driving module. Meanwhile, a set of system that can simultaneously perform IVUS and OCT imaging on the blood vessel wall is realized. The detection depth of the blood vessel tissue reaches 8 mm, the lateral resolution is better than 1 mm, the axial resolution is better than 400 μm, the lateral resolution is better than 10 μm and the axial resolution is better than 8 μm in the 1 mm range. Vascular models are built with agar and wire, and imaging experiments are performed to verify the feasibility of the system.

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中图分类号:TH773

DOI:10.3788/lop55.081701

所属栏目:医用光学与生物技术

基金项目:国家自然科学基金(61327007)、天津市自然科学基金(15JCQNJC14200)

收稿日期:2018-01-18

修改稿日期:2018-03-05

网络出版日期:2018-03-07

作者单位    点击查看

徐勇:天津大学精密仪器与光电子工程学院, 光电信息技术教育部重点实验室, 天津 300072
汪毅:天津大学精密仪器与光电子工程学院, 光电信息技术教育部重点实验室, 天津 300072
邱建榕:浙江大学光电科学与工程学院, 激光生物医学研究所, 现代光学仪器国家重点实验室, 浙江 杭州 310027
沈毅:浙江大学光电科学与工程学院, 激光生物医学研究所, 现代光学仪器国家重点实验室, 浙江 杭州 310027
肖禹泽:天津大学精密仪器与光电子工程学院, 光电信息技术教育部重点实验室, 天津 300072
陈晓冬:天津大学精密仪器与光电子工程学院, 光电信息技术教育部重点实验室, 天津 300072

联系人作者:汪毅(koala_wy@tju.edu.cn); 徐勇(xy1994@tju.edu.cn);

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引用该论文

Xu Yong,Wang Yi,Qiu Jianrong,Shen Yi,Xiao Yuze,Chen Xiaodong. IVUS-OCT Imaging System for Detection of Intravascular Lipid Plaque[J]. Laser & Optoelectronics Progress, 2018, 55(8): 081701

徐勇,汪毅,邱建榕,沈毅,肖禹泽,陈晓冬. 面向血管内脂质斑块检测的超声-OCT成像系统[J]. 激光与光电子学进展, 2018, 55(8): 081701

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