中国激光, 2018, 45 (8): 0807002, 网络出版: 2018-08-11   

基于响应面法的离体皮肤组织激光融合切口性能多元非线性回归模型 下载: 724次

Multivariate Nonlinear Regression Model of Laser Fusion in vitro Skin Tissue Incision Performance Based on Response Surface Methodology
作者单位
南京理工大学材料科学与工程学院, 江苏 南京 210094
摘要
基于响应面法设计方法对离体皮肤组织进行脉冲激光焊接实验,获得了组织切口的抗张强度和峰值温度数据; 在单因子实验的基础上,以激光功率、光斑移动速率、激光频率作为3个影响因子,建立多元非线性数学回归模型,通过方差分析和回归分析得出该回归模型的相关系数:切口抗张强度的相关系数为0.9131,切口峰值温度的相关系数为0.9985。模型分析结果表明:激光功率、光斑移动速率和激光频率3个因素的主效应和交互作用对切口性能具有很大影响,对切口抗张强度影响最大的主效应为激光功率,交互效应为激光功率与光斑移动速率; 对切口峰值温度影响最大的主效应为激光功率,交互效应为激光功率与光斑移动速率、激光功率与激光频率、光斑移动速率与激光频率。最后依据回归模型得出了最优激光工艺参数组合,回归模型预测响应值与实验结果相吻合,且切口强度满足要求。
Abstract
Based on the design method of response surface methodology, pulsed laser welding process experiment of in vitro skin tissue is performed to obtain the tensile strength and peak temperature data of tissue incision. On the basis of single factor experiment, the multivariate nonlinear mathematical regression model is established by using laser power, spot moving speed and laser frequency as the three influencing factors. Correlation coefficients of the regression model are obtained by analysis of variance and regression analysis as follows: correlation coefficient of incision tensile strength is 0.9131, correlation coefficient of incision peak temperature is 0.9985. The results of model analysis show that the main effect and interactions of laser power, spot movement speed and laser frequency have a great influence on the incision performance. The main effect that has the greatest influence on the tensile strength of incision is laser power, and the interaction effect is laser power and spot movement speed. The main effect that has the greatest influence on the peak incision temperature is laser power, and the interaction effects are laser power and spot movement speed, laser power and laser frequency, and spot movement speed and laser frequency. Finally, the optimal combination of laser process parameters is obtained based on the regression model. The experimental results show that the response values of regression model are consistent with the experimental results, and the incision strength meets the requirements.

刘其蒙, 黄俊, 王克鸿, 周琦. 基于响应面法的离体皮肤组织激光融合切口性能多元非线性回归模型[J]. 中国激光, 2018, 45(8): 0807002. Liu Qimeng, Huang Jun, Wang Kehong, Zhou Qi. Multivariate Nonlinear Regression Model of Laser Fusion in vitro Skin Tissue Incision Performance Based on Response Surface Methodology[J]. Chinese Journal of Lasers, 2018, 45(8): 0807002.

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