利用临床采集的人眼波前像差、角膜地形图和眼轴数据, 在光学软件Zemax中构建了60只个性化眼模型, 得出在瞳孔直径为6 mm和3 mm时的入射波前像差和出射波前像差.在6 mm瞳孔下, 入射波前像差大小为3.753 μm, 出射波前像差大小为3.074 μm, 差异有统计学意义(显著性值<0.05).其中, 入射波前像差和出射波前像差的离焦项差异大小为1.131 μm, 约占总差异的82%.入射波前像差和出射波前像差的球差项差异大小为0.185 μm, 约占总体差异的13%.6 mm瞳孔下, 除去高阶像差项, 出射波前像差和入射波前像差的离焦项、像散项、彗差项和球差项均具有统计学差异性.而在3 mm瞳孔下, 入射波前像差为0.804 μm, 出射波前像差为0.732 μm, 两者具有统计学差异性(显著性值<0.05).入射波前像差和出射波前像差的离焦项差异大小为0.133 μm, 约占总体差异的80%.除去像散项, 出射波前像差和入射波前像差的离焦项、彗差项、球差项和高阶像差项均具有统计学差异性.研究表明, 无论在大瞳孔还是在小瞳孔下, 人眼的入射波前像差和出射波前像差均具有统计学差异性.

Based on the clinical available wavefront aberrations of human eye, corneal topography and axial data, 60 individualized eye models were constructed in the optical software Zemax, with which the ingoing wavefront aberrations and outgoing wavefront aberrations under the pupil diameter of 6 mm and of 3 mm were obtained. When the pupil diameter is 6 mm, the ingoing wavefront aberrations and outgoing wavefront aberrations are 3.753 μm and 3.074 μm, respectively, showing a statistically significant difference(p<0.05). The difference of defocus between the ingoing wavefront aberrations and outgoing wavefront aberrations is 1.131μm, which is accounting for 82% of the whole difference. The difference of spherical aberration between the ingoing wavefront aberrations and outgoing wavefront aberrations is 0.185 μm, which contributes 13% of the total difference. Except for higher-order aberrations, the differences in defocus, astigmatism, coma and spherical aberration are statistically different in 6 mm pupil. When the pupil diameter is 3 mm, the ingoing wavefront aberrations and the outgoing wavefront aberrations are 0.804 μm and 0.732 μm, respectively, which difference is statistically significant (p<0.05). The difference in defocus is 0.133 μm, which is accounting for 80% of the total difference. Except for astigmatism, difference in defocus, coma, spherical aberration and higher-order aberrations are statistically different. The results of this study show that the difference between the ingoing wavefront aberrations and the outgoing wavefront aberrations of the human eye is statistically significant, both for large pupil and for small pupil.