Journal of Innovative Optical Health Sciences, 2018, 11 (4): 1850018, Published Online: Oct. 6, 2018  

Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells

Author Affiliations
1 Bohai Ship-building Vocational College, Huludao 125000, Liaoning, P. R. China
2 CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China
3 Jilin Weather Modification O±ce, Changchun 130062, Jilin, P. R. China
4 School of Science, Changchun University of Science and Technology, Changchun 130022, Jilin, P. R. China
5 Department of Ultrasound, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin, P. R. China
6 Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China
Abstract
In this paper, we prepared the nanoparticle drug carrier system between nanoparticles — chitosan and Epigallocatechin-3-O-gallate (EGCG) for breast cancer cell inhibiting application. For this drug carrier system, chitosan acts as a carrier and EGCG as a drug. Which were systematically characterized and thoroughly evaluated in terms of their inhibition rate and biocompatibility. We also did a cell scratch test and the result indicated that the chitosan-EGCG nanoparticles have inhibitory effect on the growth of breast cancer cells. The inhibition rate could reach up to 21.91%. This work revealed that the modification of nanoparticles paved a way for specific biomedical applications.

Yingyi Liu, Siyi Hu, Yueshu Feng, Peng Zou, Yue Wang, Pei Qin, Jie Yue, Yaotian Liang, Hui Wang, Liwei Liu. Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells[J]. Journal of Innovative Optical Health Sciences, 2018, 11(4): 1850018.

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!