为提高新生儿黄疸病的光照治疗效果,通过光谱匹配技术,设计并研制了一种新生儿黄疸治疗光源;采用研制的特殊蓝光LED光源与市售蓝光LED光源、蓝光荧光光源以及白光光源对浓度为130.932 μmol/L的体外胆红素标准液进行光照实验,光照时间分别是1,2,4,8 h,以研究胆红素的降解情况。结果表明:蓝光LED光源与蓝光荧光光源对胆红素溶液均有显著的降解效果,且自制的特殊蓝光LED光源的降解效果最佳;光源光谱是影响新生儿黄疸病治疗效果的重要因素,特殊蓝光LED能够有效降低胆红素溶液的浓度。

In order to improve the efficacy of phototherapy for neonatal jaundice, we design and develop a neonatal jaundice phototherapy light source by spectral matching technology. In order to study the degradation of bilirubin, we use the designed special blue LED source, the ordinary blue LED source, the traditional blue source, and the white LED source to irradiate standard bilirubin solution in vitro with concentration of 130.932 μmol/L for 1 h, 2 h, 4 h and 8 h, respectively. The results show that the blue LED light source and the traditional blue light source have obvious degradation effect on the bilirubin solution, and the designed special blue LED has the best degradation effect. The key factor of phototherapy for neonatal jaundice is the spectrum of the light source,and the designed special blue LED can effectively reduce the concentration of bilirubin in vitro.