We report the terahertz (THz) wave generation from a single-color scheme modulated by pre-ionized air plasma via an orthogonal pumping geometry. It is found that the amplitude of the THz signal generated by the pump beam tends to decrease gradually with the increase of the modulation power. We believe that the ponderomotive force plays an important role in the process of the interaction between the pump beam and the pre-ionization beam. The hydrostatic state of the electrostatic separation field caused by the modulation beam will directly affect the generation efficiency of the THz wave. Our results contribute to further understanding of the theoretical mechanism and expanding of the practical applications of THz wave generation and modulation.