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In vivo monitoring of microneedle-based transdermal drug delivery of insulin

In vivo monitoring of microneedle-based transdermal drug delivery of insulin

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Abstract

Soluble microneedles (MNs) have recently become an efficient and minimally invasive tool in transdermal drug delivery because of their excellent biocompatibility and rapid dissolution. However, direct monitoring of structural and functional changes of MNs in vivo to estimate the efficiency of insulin delivery is difficult. We monitored the dissolution of MNs to obtain structural imaging of MNs' changes by using optical coherence tomography (OCT). We also observed the effect of MNs on microvascular conditions with laser speckle contrast imaging (LSCI) and measured the blood perfusion of skin to obtain functional imaging of MNs. We determined the performance of two soluble MN arrays made from polyvinyl alcohol (PVA) and polyvinyl alcohol/ polyvinylpyrolidone (PVA/PVP) by calculating the cross-sectional areas of the microchannels in mouse skin as a function of time. Moreover, the change in blood glucose before and after using MNs loaded with insulin was evaluated as an auxiliary means to demonstrate the ability of the soluble MNs to deliver insulin. Results showed that the structural imaging of these MNs could be observed in vivo via OCT in real time and the functional imaging of MNs could be showed using LSCI. OCT and LSCI are potential tools in monitoring MNs structural and functional changes.

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DOI:10.1142/s1793545818500323

基金项目:This work was supported by the National Natural Science Foundation of China (Nos. 81571837, 81601534 and 61575067).

收稿日期:2018-06-06

修改稿日期:2018-08-05

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Jiawei Zhao:School of Physics and Telecom Engineering South China Normal University, No.378 West Waihuan Street Guangzhou 510006, P. R. China
Yongbo Wu:School of Physics and Telecom Engineering South China Normal University, No.378 West Waihuan Street Guangzhou 510006, P. R. China
Junbo Chen:School of Physics and Telecom Engineering South China Normal University, No.378 West Waihuan Street Guangzhou 510006, P. R. China
Bangrong Lu:School of Physics and Telecom Engineering South China Normal University, No.378 West Waihuan Street Guangzhou 510006, P. R. China
Honglian Xiong:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science College of Biophotonics, South China Normal University No.55 Zhongshan Xi Road, Guangzhou 510631, P. R. China
Zhilie Tang:School of Physics and Telecom Engineering South China Normal University, No.378 West Waihuan Street Guangzhou 510006, P. R. China
Yanhong Ji:School of Physics and Telecom Engineering South China Normal University, No.378 West Waihuan Street Guangzhou 510006, P. R. China

联系人作者:Jiawei Zhao(2015020896@m.scnu.edu.cn)

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引用该论文

Jiawei Zhao,Yongbo Wu,Junbo Chen,Bangrong Lu,Honglian Xiong,Zhilie Tang,Yanhong Ji. In vivo monitoring of microneedle-based transdermal drug delivery of insulin[J]. Journal of Innovative Optical Health Sciences, 2018, 11(5): 1850032

Jiawei Zhao,Yongbo Wu,Junbo Chen,Bangrong Lu,Honglian Xiong,Zhilie Tang,Yanhong Ji. In vivo monitoring of microneedle-based transdermal drug delivery of insulin[J]. Journal of Innovative Optical Health Sciences, 2018, 11(5): 1850032

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