Journal of Innovative Optical Health Sciences, 2015, 8 (4): 1550017, Published Online: Jan. 10, 2019  

Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device

Author Affiliations
1 Department of Stomatology, Huashan Hospital, Fudan University Shanghai, P. R. China
2 Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China
3 Department of Chemistry, Fudan University, Shanghai, P. R. China
4 Med-X Research Institute, Shanghai Jiao Tong University Shanghai, P. R. China
5 School of Biomedical Engineering, Shanghai Jiao Tong University Shanghai, P. R. China
Abstract
Photodynamic therapy (PDT) has been commonly used in treating many diseases, such as cancer and infectious diseases. We investigated the different effects of PDT on three main pathogenic bacteria of periodontitis — Prevotella melaninogenica (P.m.), Porphyromonas gingivalis (P.g.) and Aggregatibacter actinomycetemcomitans (A.a.). The portable red light-emitting diode (LED) phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations (Toluidine blue O, TBO). The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensitizers (porphyrin) under different light doses. We found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria significantly. Moreover, the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.

Xuewei Jiang, Zhichao Fan, Yili Yu, Chenying Shao, Yuanzhen Suo, Xunbin Wei, Yi Zhou. Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device[J]. Journal of Innovative Optical Health Sciences, 2015, 8(4): 1550017.

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