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Photodynamic diagnostics of early gastric cancer: Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach

Photodynamic diagnostics of early gastric cancer: Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach

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Abstract

The detection of early gastric cancer that often develops asymptomatically is crucial for improving patient survival. The photodynamic diagnosis (PDD) of gastric cancer using 5-aminolevulinic acid/protoporphyrin IX (5-ALA/PpIX) has been reported in several studies. However, the selectivity of PDD of gastric tumor is poor with often false-positive results that require the development of new methods to improve PDD for early gastric cancer. Therefore, a measure of the complexity of gastric microcirculation (multi-scale entropy, MSE) and the detrended fluctuation analysis (DFA) were applied as additional tools to detect early gastric cancer in rats.In this experimental study, we used our original model of metastatic adenocarcinoma in the stomach of a rat. To induce a gastric tumor, we used a long-term combination (for 9 months, which is 1/2 of the life of rats) of two natural factors, such as chronic stress (overpopulation being typical for modern cities) and the daily presence of nitrites in food and drinks, which are common ingredients added to processed meat and fish to help preserve food. Our results clearly show that both methods, namely, PDD using 5-ALA/PpIX and complexity/correlation analysis, can detect early gastric cancer, which was confirmed by histological analysis. Pre-cancerous areas in the stomach were detected as an intermediate fluorescent signal or MSE level between normal and malignant lesions of the stomach. However, in some cases, PDD with 5-ALA/PpIX produced a false-positive fluorescence of exogenous fluorophores due to its accumulation in benign and inflammatory areas of the mucosa. This fact indicates that the PDD itself is not sufficient for the correct diagnosis of gastric cancer, and the use of additional characteristics, e.g., complexity measures or scaling exponents, can significantly improve the diagnostic accuracy of PDD of gastric cancer that should be confirmed in further clinical studies and applications.

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DOI:10.1142/s179354581950007x

基金项目:This collaborative work was supported in the frames of Russian Science Foundation project #18-15-00139 “Optical technologies for early diagnostics of stomach cancer." Fluorescence measurements were made using spectrometric system purchased in the frames of Bulgarian NSF-MES project #DFNIB02/9/2014 “Development of biophotonics methods as a basis of oncology theranostics."

收稿日期:2018-11-06

修改稿日期:2019-03-08

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Alexey Pavlov:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, Russia
Ekaterina Borisova:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, RussiaInstitute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee Blvd. 72, Sofia 1784, Bulgaria
Olga Pavlova:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, Russia
Ilana Agranovich:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, Russia
Alexander Khorovodov:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, Russia
Andrey Terskov:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, Russia
Aysel Mamedova:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, Russia
Maria Klimova:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, Russia
Latchezar Avramov:Institute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee Blvd. 72, Sofia 1784, Bulgaria
Oxana Semyachkina-Glushkovskaya:Saratov State University, 83 Astrakhanskaya Str., Saratov 410012, Russia

联系人作者:Ekaterina Borisova(borisova@ie.bas.bg)

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引用该论文

Alexey Pavlov,Ekaterina Borisova,Olga Pavlova,Ilana Agranovich,Alexander Khorovodov,Andrey Terskov,Aysel Mamedova,Maria Klimova,Latchezar Avramov,Oxana Semyachkina-Glushkovskaya. Photodynamic diagnostics of early gastric cancer: Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach[J]. Journal of Innovative Optical Health Sciences, 2019, 12(2): 1950007

Alexey Pavlov,Ekaterina Borisova,Olga Pavlova,Ilana Agranovich,Alexander Khorovodov,Andrey Terskov,Aysel Mamedova,Maria Klimova,Latchezar Avramov,Oxana Semyachkina-Glushkovskaya. Photodynamic diagnostics of early gastric cancer: Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach[J]. Journal of Innovative Optical Health Sciences, 2019, 12(2): 1950007

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