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Photoacoustic reporter genes for noninvasive molecular imaging and theranostics

Photoacoustic reporter genes for noninvasive molecular imaging and theranostics

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Abstract

Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and spatial resolution in deep tissue. Among the various probes developed for PAI, genetically encoded reporters attracted increasing attention of researchers, which provide improved performance by acquiring images of a PAI reporter gene's expression driven by disease-specific enhancers/promoters. Here, we present a brief overview of recent studies about the existing photoacoustic reporter genes (RGs) for noninvasive molecular imaging, such as the pigment enzyme reporters, fluorescent proteins and chromoproteins, photoswitchable proteins, including their properties and potential applications in theranostics. Furthermore, the challenges that PAI RGs face when applied to the clinical studies are also examined.

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DOI:10.1142/s1793545820300050

基金项目:This work was supported by the Major State Basic Research Development Program of China (2017YFA0205201 and 2018YFA0107301), the National Natural Science Foundation of China (81422023, 81925019, 81603015, 81801817, U1705281, and U1505221), the Fundamental Research Funds for the Central Universities (20720190088), Natural Science Foundation of Fujian Province (2016J05202 and JT180649), and the Program for New Century Excellent Talents in University, China (NCET-13-0502).

收稿日期:2019-11-04

修改稿日期:2019-12-14

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Zhao Lei:State Key Laboratory of Molecular Vaccinology and Molecular, Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, P. R. China
Yun Zeng:Department of Pharmacy, Xiamen Medical College, Xiamen, Fujian 361023, P. R. China
Xiaofen Zhang:State Key Laboratory of Molecular Vaccinology and Molecular, Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, P. R. China
Xiaoyong Wang:State Key Laboratory of Molecular Vaccinology and Molecular, Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, P. R. China
Gang Liu:State Key Laboratory of Molecular Vaccinology and Molecular, Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, P. R. China

联系人作者:Xiaoyong Wang(wangxy@xmu.edu.cn)

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引用该论文

Zhao Lei,Yun Zeng,Xiaofen Zhang,Xiaoyong Wang,Gang Liu. Photoacoustic reporter genes for noninvasive molecular imaging and theranostics[J]. Journal of Innovative Optical Health Sciences, 2020, 13(3): 2030005

Zhao Lei,Yun Zeng,Xiaofen Zhang,Xiaoyong Wang,Gang Liu. Photoacoustic reporter genes for noninvasive molecular imaging and theranostics[J]. Journal of Innovative Optical Health Sciences, 2020, 13(3): 2030005

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