无机材料学报, 2020, 35 (5): 601, 网络出版: 2021-03-01  

牡蛎壳为原料制备医用CaCO3/HA复合生物材料 下载: 511次

Preparing Biomedical CaCO3/HA Composite with Oyster Shell
作者单位
天津大学 材料科学与工程学院, 天津 300350
摘要
以牡蛎壳为原材料, 通过水热法制备了碳酸钙(CaCO3)/羟基磷灰石(HA)复合材料, 拟达到降低HA生产成本并改善其降解性能的目的。通过物相分析和SEM、TEM观察发现制得的CaCO3/HA复合材料呈现片层状, 其微观形貌呈现纳米颗粒状。实验通过控制钙、磷元素的投料比例制备了HA含量为20%、40%、60%的三种CaCO3/HA复合材料(20%HA、40%HA、60%HA), 通过ICP测试计算得出HA的实际含量为17.52%、34.30%、43.24%。随着HA含量的增加, CaCO3/HA复合材料的比表面积和热稳定性显著提升。体外降解实验结果表明, 三种不同HA含量的复合材料在PBS模拟体液中14 d的降解率分别为15.2%, 12.0%和10.8%, 降解率随HA比例的增高而降低。这些结果表明: 水热法合成CaCO3/HA复合材料可通过钙、磷元素的投料比例来调控HA的转化率, 进而调控CaCO3/HA复合材料的降解速率, 实现其在骨科领域的潜在应用。
Abstract
To reduce the cost of HA and improve degradation performance of HA, oyster shells were used as raw materials to prepare CaCO3/ hydroxyapatite (HA) composite materials by a hydrothermal method. Phase analysis and SEM/TEM observation revealed that as-prepared CaCO3/HA composites had a morphology of HA nanoparticles growing on the lamellar CaCO3. Three kinds of CaCO3/HA composites (20%HA、40%HA、60%HA) with HA content of 20%, 40% and 60% were prepared by controlling the proportion of calcium and phosphorus. The actual content of HA in three obtained different composites, determined by ICP, were 17.52%, 34.30% and 43.24%, respectively. With the increase of HA content, the specific surface area and thermal stability of CaCO3/HA composite are improved. Samples were immersed in PBS simulated body fluid for 14 d to evaluate their in vitro degradation ability. The results showed that degradation rates of three kinds of composites with different HA contents (20%HA, 40%HA and 60%HA) were 15.2%, 12.0% and 10.8%, respectively. The degradation rate decreased with the increase of HA proportion in the composite. All data indicates that the hydrothermal synthesis of CaCO3/HA composite can control the conversion degree of HA and then adjust the degradation rate of CaCO3/HA composite by designing the ratio of calcium and phosphorus elements, which have potential application in orthopedics.

刘子阳, 耿振, 李朝阳. 牡蛎壳为原料制备医用CaCO3/HA复合生物材料[J]. 无机材料学报, 2020, 35(5): 601. Ziyang LIU, Zhen GENG, Zhaoyang LI. Preparing Biomedical CaCO3/HA Composite with Oyster Shell[J]. Journal of Inorganic Materials, 2020, 35(5): 601.

引用该论文: TXT   |   EndNote

相关论文

加载中...

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!