光纤表面等离子体共振(SPR)传感器结合了光纤传感器的微型化、可在线传输、易操作和SPR生物检测技术的高灵敏、高选择性、免标记等优势，是当前免疫学生物传感器的研究热点。但传统多模光纤SPR传感器的信号在远距离传输中易损耗、失真。文中提出了一种单模-无心-单模光纤型SPR传感器，能有效减小信号传输中的损耗与失真，且适合与当前的光纤网络衔接。为了消除传感器中的干扰信号，改变无心光纤的芯径，采用去除背景干扰，高斯拟合等方法，最终选取了具有芯径为61.5 μm无心光纤的此类传感器，并从中提取出了有效的SPR光谱信号。传感器的灵敏度为1153.40 nm/RIU，分辨率为1.70×10^?4 RIU。此类光纤生物传感器的成功开发，为智慧医疗、远程医疗提供了一种新的思路。

Optical fiber surface plasmon resonance (SPR) sensor combines the advantages of optical fiber sensor like miniaturization, online transmission, easy operation and SPR biodetection technology, which is highly sensitive, highly selective and label-free. It is currently a research hotspot of immunological biosensors. However, the signal of traditional multi-mode fiber based SPR sensor is easy to be lost and distorted in long-distance transmission. In this paper, a single mode-no core-single mode fiber based SPR sensor was proposed, which could effectively reduce the loss and distortion in signal transmission, and was suitable for connecting with the current optical fiber network. In order to eliminate the interference signal in the sensor, the core diameter of the no core fiber was changed, the methods of removing background interference and Gaussian fitting were adopted, and finally the sensor with the sensing region of 61.5 μm no core fiber was selected, the effective SPR spectrum signal was extracted from it. The sensitivity of proposed sensor is 1153.40 nm/RIU and the resolution is 1.70×10^-4 RIU. The successful development of this kind of optical fiber biosensor provides a new idea for intelligent medical treatment and telemedicine.