中国激光, 2019, 46 (6): 0614017, 网络出版: 2019-06-14
左旋多巴宽频太赫兹光谱研究 下载: 1125次
Broadband Terahertz Spectroscopy of Levodopa
太赫兹技术 左旋多巴 宽频太赫兹时域光谱 密度泛函理论 低频振动 氢键网络 terahertz technology levodopa broadband terahertz time-domain spectroscopy density functional theory low frequency vibration hydrogen bonding network
摘要
利用空气等离子体太赫兹时域光谱系统,获得了0.5~14.5 THz范围内左旋多巴(L-DOPA)的特征指纹谱,并研究了吸收光谱随温度的变化效应。利用密度泛函理论计算L-DOPA的晶胞结构,并对太赫兹振动光谱进行了分析。结果表明:L-DOPA在太赫兹波段的吸收峰对应于不同的集体振动和分子局域振动,其中分子的集体振动在整个太赫兹波段分布较广,且苯环和分子侧链表现出不同的振动特点,这些结构振动特异性与分子构象以及分子间氢键的相互作用密切相关。
Abstract
The characteristic fingerprint spectrum of levodopa (L-DOPA) in the frequency range of 0.5-14.5 THz was obtained by using an air plasma terahertz time-domain spectroscopy system, and the variation in absorption spectrum with temperature was investigated. Density functional theory was used to calculate the L-DOPA crystal cell structure and for the spectral analysis of terahertz vibration. The results show that L-DOPA terahertz absorption peaks correspond to different collective vibrations and molecular local vibrations. The collective vibrations of L-DOPA have a wide distribution in the terahertz range, and the benzene ring and molecular side chain exhibit distinct vibrational modes. The vibration specificity is closely related to the molecular conformation and hydrogen-bonding interactions.
朱中杰, 任冠华, 成超, 吴志鹏, 张建兵, 韩家广, 赵红卫. 左旋多巴宽频太赫兹光谱研究[J]. 中国激光, 2019, 46(6): 0614017. Zhongjie Zhu, Guanhua Ren, Chao Cheng, Zhipeng Wu, Jianbing Zhang, Jiaguang Han, Hongwei Zhao. Broadband Terahertz Spectroscopy of Levodopa[J]. Chinese Journal of Lasers, 2019, 46(6): 0614017.