中国激光, 2019, 46 (1): 0107001, 网络出版: 2019-01-27   

基于锁相光子计数的多通道脑功能成像系统 下载: 741次

Multi-Channel Brain Functional Imaging System Based on Lock-in Photon Counting
作者单位
1 天津大学精密仪器与光电子工程学院, 天津 300072
2 天津大学天津市生物医学检测技术与仪器重点实验室, 天津 300072
摘要
功能近红外光谱成像已成为脑功能研究的首选手段。为得到高灵敏度、大动态范围以及高时间分辨率的成像系统, 开发了基于改进锁相光子计数的多通道近红外脑功能成像系统。光源模块由波长为785, 808, 830 nm的激光二极管(各16个)组成, 调制方波的频率间隔为252 Hz; 探测模块包括9个光子计数式光电倍增管。该系统结合了单光子计数技术的超高灵敏度与方波调制模式数字锁相检测的简易并行性, 测量线性相关系数可达0.9989, 信道间的串扰可忽略不计, 具有较强的抗干扰能力和准确的空间定位能力。
Abstract
Functional near-infrared spectroscopy imaging has become the preferred choice as a neuroimaging technique of brain function research. To obtain the imaging system with high sensitivity, large dynamic range and high temporal resolution, we develop a multi-channel near-infrared brain functional imaging system based on improved lock-in photon-counting. The light source module consists of 16 laser diodes with wavelength of 785, 808 and 830 nm, respectively, which are modulated by square wave with frequency space of 252 Hz. The detection module includes nine photon counting photomultiplier tubes. This system combines the ultra-high sensitivity of the photon-counting technology with the simple parallelism of the digital lock-in detection based on square wave modulation mode, and system performance meets requirements. The linear correlation coefficient can reach 0.9989, cross talk between channels is negligible. The system has strong anti-interference ability and the ability to locate accurately.

丁雪梅, 王兵元, 刘东远, 张耀, 潘甜甜, 高峰. 基于锁相光子计数的多通道脑功能成像系统[J]. 中国激光, 2019, 46(1): 0107001. Ding Xuemei, Wang Bingyuan, Liu Dongyuan, Zhang Yao, Pan Tiantian, Gao Feng. Multi-Channel Brain Functional Imaging System Based on Lock-in Photon Counting[J]. Chinese Journal of Lasers, 2019, 46(1): 0107001.

本文已被 4 篇论文引用
被引统计数据来源于中国光学期刊网
引用该论文: TXT   |   EndNote

相关论文

加载中...

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!