Through the realworld study with a large sample size,itwas conducted to evaluate the efficacy of a ring microstructure designed defocus lens in slowing or controlling myopia in adolescents in realistic clinical settings,which was iBright? defocus lens,and the control product was ordinary single vision lens. Propensity score matching (PSM) was used to controlconfounding bias. The progression of myopia was assessed by the change of axial length and spherical equivalent determined by objective refraction under cycloplegia. The 6-monthfollow-up results showed thatthe totaleffective rate of iBright? defocus lens in slowing the progression of spherical equivalentwas 54.9% and in slowing the progression of axial length was 63.4%. iBright? defocus lens can effectively slow or controlthe progression of myopia.