In this paper, we present a distal-scanning common path probe for optical coherence tomography (OCT) equipped with a hollow ultrasonic motor and a simple and specially designed beam-splitter. This novel probe proves to be able to effectively circumvent polarization and dispersion mismatch caused by fiber motion and is more robust to a variety of interfering factors during the imaging process, experimentally compared to a conventional noncommon path probe. Furthermore, our design counteracts the attenuation of backscattering with depth and the fall-off of the signal, resulting in a more balanced signal range and greater imaging depth. Spectral-domain OCT imaging of phantom and biological tissue is also demonstrated with a sensitivity of ～100dB and a lateral resolution of ～3μm. This low-cost probe offers simplified system configuration and excellent robustness, and is therefore particularly suitable for clinical diagnosis as one-off medical apparatus.

光学相干层析成像（OCT）是一种高空间分辨率的光学成像方法，可以对生物组织进行非接触、无标记的二维截面和三维体积成像，能为临床疾病的诊断提供具有重要参考价值的影像信息。在传统的台式OCT系统中，扫描探头被固定在工作台上，探头结构较大，灵活性差，不利于深入狭小腔体内部成像或在床旁检测。本团队设计了一种视频引导的手持式高速OCT系统，其手持探头结构紧凑、体积小巧，便于抓取和深入狭小腔体内部；探头内部集成了相机成像功能，可以实时获得成像区域的视频图像，引导OCT成像。该系统的A线扫描速率可以达到200 kHz。为了克服成像过程中的抖动问题，本团队提出了图像自动配准算法，该算法能显著提高图像质量。采用该系统对离体猪眼角膜和离体猪牙齿进行成像，以验证系统的性能。结果显示该系统能够高速获取高分辨的组织图像。

研究了批量制备的锥形光纤表面增强拉曼散射（SERS）探针的定量检测性能。在统一的制备条件下，基于静电吸附自组装方法批量制备的同一批次锥形光纤探针具有良好的互换性。基于相同检测条件，在同一福美双样品浓度下测得SERS光谱幅度的相对标准偏差（RSD）可达8%以下。不同批次的光纤探针存在互换性退化问题，难以满足实际定量检测应用对光纤探针数目的要求。为了解决该问题，提出并演示了一种将不同批次光纤探针的光谱数据同化至同批次光纤探针测量结果的同化方法。通过对同化后的大样本光谱数据进行统计平均和数据拟合，获得了福美双样品在2×10^-8~10^-6 mol/L浓度范围内的SERS定量关系曲线，福美双加标样品的测试回收率可达90%~110%。该研究结果对于实际SERS定量检测具有参考意义。

提出一种基于多点的虚实注册方法。首先，设计一种手持式靶标探针，根据飞机零部件上的典型特征设计了不同的探针测头，并采用单目相机对探针进行标定，标定出测头尖点相对靶标的位置。然后，在虚实注册过程中在三维模型上设置几个点，借助靶标探针测量真实零件上对应的几个点，利用奇异值矩阵分解法，求解出增强现实设备虚实映射空间中三维模型到真实零件的刚体变换，根据此变换即可实现虚实配准。最后，选取3 m×1.4 m×0.5 m尺寸范围内的机翼为验证对象，采用所设计的靶标探针验证其虚实配准精度，并分析注册时点的数量与布局对虚实注册精度的影响。实验结果表明，所提方法可以实现大尺寸零部件整体较高的虚实配准精度。

The paper presents the results of an experimental study of the local polarization reversal and creation of domains by a biased tip of scanning probe microscope (SPM) in lithium niobate single crystals of congruent composition with a surface layer modified by soft proton exchange (SPE). The depth dependence of H+ ions concentration in the SPE-modified layer measured by confocal Raman microscopy demonstrates a sufficient composition gradient. The creation of isolated domains and stripe domain structures has been done by two switching modes: (1) point switching by field application in separated points and (2) line scanning switching by motion of the biased tip being in contact with the sample surface. For point switching for pulse durations less than 10s, the logarithmic dependence of the domain diameter on the pulse duration was observed. The change of the dependence to a linear one for pulse duration above 10s has been attributed to the transition from the stochastic step generation at the domain wall to the deterministic one at the domain vertexes. The periodical structure of stripe domains was created in SPE CLN planar waveguides by scanning at elevated temperature. The revealed switching regime suppresses electrostatic interaction of neighboring domains and leads to a significant improvement of the domain structure regularity. The creation of the stable periodical domain structure with submicron periods in SPE CLN planar waveguides was demonstrated.