激光与光电子学进展, 2019, 56 (16): 161701, 网络出版: 2019-08-05
光声弹性成像技术在动脉血压监测中的应用研究 下载: 1194次
Application of Photoacoustic Elastography Technique in Arterial Blood-Pressure Monitoring
医用光学 光声信号 弹性成像技术 血管管径 压力 medical optics photoacoustic signal elastography technology vessel diameter pressure
摘要
基于血管弹性成像原理,利用光声成像技术测量不同压力作用下血管内径的变化情况,通过建立光声信号的时域特征模型,计算用于分析血压-管径特征关系的信息,再结合希尔伯特变换等数字信号处理方法进行分析,由此获得了组织中弹性力学性质的空间分布情况。实验结果表明:压力、血管管径与光声信号峰峰值的时间间隔呈单调递增的关系,该技术可用于快速、实时地检测血管直径的变化,为光声成像技术实现非侵入式动态血压测量提供了理论依据。
Abstract
Based on the angio elastography principle, the variation in blood-vessel diameter with pressure is measured by the photoacoustic elastography technique. A characteristic time-domain model for photoacoustic signals is developed to analyze the information of the blood pressure-diameter relation. A series of digital signal-processing methods based on the Hilbert transform are used to obtain spatial distributions of elastic mechanical properties in tissues. Results demonstrate that the pressure and vessel diameter have a monotonously increasing relation with the photoacoustic-signal time interval, which can be used to dynamically and quickly detect changes in the vessel diameter. This method provides a theoretical basis for non-invasive ambulatory blood-pressure measurements by photoacoustic imaging.
章小曼, 翁存程, 朱莉莉, 蔡坚勇, 吴淑莲, 李志芳, 吴华钦, 李晖. 光声弹性成像技术在动脉血压监测中的应用研究[J]. 激光与光电子学进展, 2019, 56(16): 161701. Xiaoman Zhang, Cuncheng Weng, Lili Zhu, Jianyong Cai, Shulian Wu, Zhifang Li, Huaqin Wu, Hui Li. Application of Photoacoustic Elastography Technique in Arterial Blood-Pressure Monitoring[J]. Laser & Optoelectronics Progress, 2019, 56(16): 161701.