中国激光, 2017, 44 (1): 0102014, 网络出版: 2017-01-10
皮秒激光对医用钛合金植入物表面微加工及生物相容性的研究 下载: 1671次
Micromachining of Titanium Alloy Implant by Picosecond Laser Surface Texturing and Alloy Biocompatibility
激光制造 皮秒激光 表面微造型 钛合金植入物 生物相容性 laser manufacturing picosecond laser surface texture titanium alloy implants biocompatibility
摘要
钛合金具有优良的综合性能, 作为医用金属植入材料广泛应用于临床医学, 而在钛合金植入物表面进行微造型有助于提高钛合金的生物相容性。采用1064 nm波长的皮秒激光在钛合金(Ti-6Al-4V)表面进行微造型实验, 并验证微造型的生物相容性。设计正交实验, 通过扫描电子显微镜、扫描探针显微镜和共聚焦显微镜分析了样件表面形貌, 建立微造型几何尺寸与激光参数的关系, 确立了最优工艺参数, 完成钛合金微造型样件制备。进行了大鼠骨髓间充质干细胞培养和免疫荧光观察细胞骨架实验。实验表明, 微造型对细胞生长起到促进和引导作用。
Abstract
Titanium alloy has excellent comprehensive properties, and it is widely used in clinical applications. Studies show that it is helpful to improve the biocompatibility of titanium alloy implant by introducing specific textures to the surface. A pulsed picosecond laser emitting at 1064 nm was used to process titanium alloy (Ti-6Al-4V), and the biocompatibility of laser textures was verified. Orthogonal experiments were designed, and the surface morphology of the samples was analyzed by using scanning electron microscope, scanning probe microscope and confocal microscope. The relationship between surface morphology of titanium alloy and picosecond laser processing parameters was investigated in order to determine the optimal process parameters. Meanwhile, cell culture and actin cytoskeleton staining were conducted. The experiments show that the picosecond laser surface texturing plays a role in promoting and guiding growth of cells.
虞宙, 张文杰, 胡俊. 皮秒激光对医用钛合金植入物表面微加工及生物相容性的研究[J]. 中国激光, 2017, 44(1): 0102014. Yu Zhou, Zhang Wenjie, Hu Jun. Micromachining of Titanium Alloy Implant by Picosecond Laser Surface Texturing and Alloy Biocompatibility[J]. Chinese Journal of Lasers, 2017, 44(1): 0102014.