光学学报, 2018, 38 (5): 0517001, 网络出版: 2018-07-10
扫频光学相干层析成像应用于判断黏液型胃癌边界区域 下载: 1090次
Boundary Region of Stomach Mucinous Carcinoma with Swept Source Optical Coherence Tomography
医用光学 黏液型胃癌 扫频光学相干层析成像 癌症边界 手术导航 三维重建 medical optics stomach mucinous carcinoma swept source optical coherence tomography cancer boundary surgery guide three-dimensional reconstruction
摘要
为了在癌症外科手术中提供实时反馈,更精确地切除癌症组织,从而在术中导航领域展现应用潜力,利用光学相干层析成像(OCT)系统对39例胃癌患者肿瘤组织成像,并与对应位置的病理切片进行对比。结果表明:有效的38个病例的OCT图像能清晰地分辨癌症组织与正常组织的差别,其中有4例黏液型胃癌,黏液型胃癌的肿瘤分泌的黏液会破坏胃组织的层状结构,导致纹理紊乱,黏膜残缺;黏液对光的背向散射更弱以及与黏膜组织的背向散射对比相差更大使得黏液型胃癌的OCT图像成像更清晰,B型超声扫描(B-scan)的OCT图像能够分辨该种类型癌症的边界区域;将B-scan的OCT图像进行三维(3D)重建后显示整个成像区域的体结构,经过表面展平后提取深度方向上不同层的切面图像,提供了另一维度视角观察胃癌组织的边界区域,与B-scan图像交叉验证可以显示优异的区分效果。
Abstract
To provide a real-time intraoperative feedback and suggest an applied potential to guide stomach cancer surgery for removal of normal tissue as little as possible, we use an optical coherence tomography (OCT) to image normal tissue and tumor tissue of 39 stomach cancerous patients, and compare OCT images and pathological sections. The results show that OCT images of 38 patients show obvious difference between normal tissue and tumor tissue. For the 4 stomach mucinous carcinomas, the mucus secreted by tumor of stomach mucinous carcinoma destroys the layer structure, texture, and mucosa of stomach tissue. The poorer backscattering of mucus and the greater difference between backscattering of mucosal tissue make the OCT images of stomach mucinous carcinoma clearer. The B-mode ultrasonic scanning (B-scan) OCT images can distinguish the boundary of the cancerous tissue and the normal tissue. A volumetric image can be built with B-scan images by the three-dimensional (3D) reconstruction method. The layered section images in tissue-depth direction are obtained after volumetric surface flattening. These images provide another dimensionality to view stomach cancerous boundary. The cross validation with B-scan images can show excellent distinction.
罗斯特, 范应威, 常玮, 安昕, 赵辉, 霍力. 扫频光学相干层析成像应用于判断黏液型胃癌边界区域[J]. 光学学报, 2018, 38(5): 0517001. Site Luo, Yingwei Fan, Wei Chang, Xin An, Hui Zhao, Li Huo. Boundary Region of Stomach Mucinous Carcinoma with Swept Source Optical Coherence Tomography[J]. Acta Optica Sinica, 2018, 38(5): 0517001.