为了在甲状腺手术中辅助医生对切除的颈部组织进行快速的组织学判断,使用自行搭建的光学相干层析(OCT)系统对行甲状腺切除术及淋巴结清扫术患者的切除组织进行三维成像,并将其与二维OCT图像以及病理切片进行对比。对21个病例的切除组织分别采集67幅1000 pixel×1000 pixel×630 pixel的高分辨三维OCT图像,对应6 mm×6 mm×3.8 mm的成像范围。可以从不同角度和不同的内部切面对三维OCT图像进行观察,能够清楚地辨别成像范围内的甲状腺、甲状旁腺、淋巴结和脂肪组织,并能够清楚地分辨淋巴结转移病变。高速、高分辨的三维OCT成像为甲状腺手术提供了一种术中病理诊断的方式,在辅助医生做出手术决策方面具有一定的应用潜力。

In order to assist the surgeons in the fast histological inspection of the excised tissues during the thyroid surgery, a home-made optical coherence tomography (OCT) system is used for the three-dimensional (3D) imaging of the excised tissues from the patients receiving the thyroid surgery and lymphadenectomy. The 3D OCT images are also compared with the corresponding two-dimensional OCT images and the histological images. The 67 high-resolution 3D OCT images with 1000 pixel×1000 pixel×630 pixel are acquired from the excised tissues of the 21 patients and the corresponding imaging range is 6 mm×6 mm×3.8 mm. It is convenient to observe the 3D OCT images from different perspectives or cross-sectional planes. The thyroid, parathyroid, lymph node and fat within the imaging range can be clearly identified, and the malignant lesions of lymphatic metastasis can also be distinguished. This high speed and high resolution 3D OCT imaging provides a method for the intraoperative histopathology and is promising to assist the surgeons for their intraoperative decision.