应用激光, 2019, 39 (4): 716, 网络出版: 2019-10-12  

超声导入bFGF辅助CO2点阵激光治疗痤疮瘢痕的临床观察

Clinical Observation on CO2 Fractional Laser Assisted with Ultrasonic bFGF Delivery in the Treatment of Acne Scars
作者单位
1 廊坊市第四人民医院超声科, 河北 廊坊 065700
2 廊坊市第四人民医院皮肤科, 河北 廊坊 065700
摘要
目的: 探讨超声导入碱性成纤维细胞生长因子(bFGF)对CO2点阵激光治疗痤疮瘢痕疗效及不良反应的影响。方法: 回顾分析2016年1月至 2019年2月79例痤疮瘢痕患者的临床资料, 根据治疗方法的不同分为对照组(n=43, CO2点阵激光治疗)和研究组(n=36, CO2点阵激光治疗+超声导入bFGF治疗)。比较两组临床疗效, 记录两组创口愈合时间、红斑持续时间、误工期、不良反应发生率以及患者舒适度和外观满意度, 观察两组治疗前后瘢痕ECCA评分及皮肤红斑指数、黑素指数、经皮水分丢失量(TEWL)和角质层含水量。结果: ①研究组治疗总有效率为91.67%(33/36), 高于对照组的79.07%(34/43), 但差异无统计学意义(P>0.05)。②研究组创口愈合时间、红斑持续时间、误工期短于对照组, 不良反应发生率低于对照组, 差异均有统计学意义(P<0.05)。患者舒适度和满意度均高于对照组(P<0.05)。③两组治疗前ECCA评分及皮肤红斑指数、黑素指数、TEWL、角质层含水量无统计学差异(P>0.05), 治疗后ECCA评分、红斑指数、黑素指数TEWL明显下降(P<0.05), 角质层含水量明显增高(P<0.05), 但研究组ECCA评分、黑素指数、TEWL、角质层含水量改善幅度大于对照组(P<0.05)。结论: 超声导入bFGF有助于提高CO2点阵激光治疗痤疮瘢痕的疗效和减少不良反应。
Abstract
Objective: to discuss the effect of CO2 fractional laser assisted with ultrasonic basic fibroblast growth factor(bFGF) delivery on acne scars and its influence on adverse reactions. Methods: 79 cases of patients with acne scars in our hospital from January 2016 to February 2019 were analyzed retrospectively, according to the different treatment methods, the patients were divided into the control group (n=43, CO2 fractional laser treatment) and the study group (n=36, CO2 fractional laser treatment + ultrasonic bFGF delivery treatment). The clinical efficacy of the two groups was compared, and the wound healing time, erythema duration, time of missed work, incidence of adverse reactions, comfort and appearance satisfaction of the patients in the two groups were recorded. The scar ECCA score, erythema index, melanin index, transepidermal water loss (TEWL) and cuticle moisture content before and after treatment in the two groups were observed.Results: ①The total effective rate in the study group was 91.67% (33/36), higher than that in the control group (79.07%(34/43), but the difference was not statistically significant (P>0.05).②The wound healing time, duration of erythema and time of missed work in the study group were shorter than those in the control group, and the incidence of adverse reactions was lower than that in the control group, with statistically significant differences (P<0.05).The comfort degree and satisfaction degree of the patients were higher than those of the control group (P<0.05).③ECCA score , erythema index, melanin index,TEWL,water content of cuticle were no statistical difference (P>0.05) before treatment between the two groups, ECCA score, erythema index, the index of melanin TEWL significantly decreased (P<0.05) and cuticle moisture content significantly increased (P<0.05) after treatment in the two groups, but the improvement of ECCA score, melanin index, TEWL and cuticle moisture content in the study group was greater than that of the control group (P<0.05).Conclusion :Ultrasonic bFGF delivery can improve the efficacy of CO2 fractional laser in the treatment of acne scars and reduce adverse reactions.

苏美娜, 陈永平. 超声导入bFGF辅助CO2点阵激光治疗痤疮瘢痕的临床观察[J]. 应用激光, 2019, 39(4): 716. Su Meina, Chen Yongping. Clinical Observation on CO2 Fractional Laser Assisted with Ultrasonic bFGF Delivery in the Treatment of Acne Scars[J]. APPLIED LASER, 2019, 39(4): 716.

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