光热治疗基于光热药剂在激光照射下产生热量, 进而高温杀死肿瘤细胞, 因而实时监测光热过程中微观温度变化对于优化治疗效果具有十分重要的作用。稀土Eu3+配合物的发光具有线谱、长荧光寿命以及对温度高度敏感的特点, 利用Eu3+配合物的温敏特性可检测光热过程中的温度变化, 整合温度监测功能和光热特性的纳米体系在光热治疗领域具有很好的应用前景。本文制备了一种内部封装温度敏感探针Eu3+配合物且表面复合金纳米球的功能纳米颗粒, 将该功能纳米颗粒分散液置于不同的温度环境中, 发现其荧光性能对温度具有高的响应灵敏度, 即Eu3+的特征发射峰(615 nm)强度随温度升高降低52.7%, 表明该稀土荧光温度纳米传感器具有高的温度敏感性。在激光辐照下, 功能纳米颗粒可以产生良好的光热现象, 基于自身的温敏特性可实时对光热特性进行温度监控。

Photothermal therapy is based on the heat generated by photothermal agents under laser irradiation, and then kills tumor cells at high temperature. Real-time monitoring of microscopic temperature changes in photothermal process plays a very important role in optimizing the therapeutic effect. Europium(Ⅲ) chelates display line spectrum, long fluorescence lifetime and a highly temperature-dependent emission, which can be used to detect the temperature of photothermal process. The nanosystem, integrating temperature monitoring and the photothermal property, is promissing in the field of photothermal therapy. Herein, we designed a gold nanospheres-attached Eu(TTA)3-(TPPO)2-loaded functional nanomaterials. The functional nanoparticle displays good temperature-dependent fluorescence performance. The emission peak(615 nm) of Eu3+ decreases up to 52.7% from 35 ℃ to 65 ℃, indicating that the nanoparticles has high temperature sensitivity. Under laser irradiation, functional nanoparticles can produce photothermal effects, and real-time temperature monitoring of photothermal process can be performed based on its own temperature sensitivity.