光学学报, 2020, 40 (6): 0630001, 网络出版: 2020-03-06
基于太赫兹时域光谱的青霉素类药物检测研究 下载: 1239次
Study on Detection of Penicillin Drugs Based on Terahertz Time-Domain Spectroscopy
光谱学 太赫兹时域光谱 青霉素类 定性鉴别 定量分析 spectroscopy terahertz time-domain spectroscopy penicillin qualitative identification quantitative analysis
摘要
青霉素类药物在临床上的应用十分广泛,此类药物的真伪鉴别以及药物含量的鉴定是极其重要的。利用自主搭建的太赫兹时域光谱系统,对纯青霉素钠和三种不同厂家的阿莫西林胶囊进行了测试分析,获得了四种药品在0.2~1.4 THz波段的吸收谱,发现它们均存在明显的吸收峰。同时,在相同质量下测试了纯青霉素钠和不同含量的阿莫西林在吸收峰强度上的变化,分别得到了四种药品的质量和强度的对应关系。最后将阿莫西林三种药品的强度放在一起进行对比,可直观地看到含量和强度之间的对应关系。对纯青霉素钠和阿莫西林的光谱研究结果表明:利用太赫兹光谱可对青霉素类药物进行定性鉴定和定量分析,这对青霉素类药品的物质鉴别等有重要意义。
Abstract
The clinical application of penicillin is very extensive, and it is extremely important for the authenticity identification of such drugs and the identification of drug content. In this paper, the self-built terahertz time-domain spectroscopy system is used to test and analyze the pure penicillin sodium and amoxicillin capsules from three different manufacturers. The absorption spectra of four drugs in the range of 0.2-1.4 THz and the obvious absorption peaks are obtained. At the same time, the changes of absorption peak intensity of pure penicillin sodium and amoxicillin with different contents under the same mass are tested, and the corresponding relationship between the mass and intensity is clearly obtained. Finally, the intensities of three amoxicillin drugs are put together for comparison, and the correspondence between the content and the intensity can be visually seen. Spectroscopic study results on pure penicillin sodium and amoxicillin show that terahertz spectroscopy can be used for qualitative identification and quantitative analysis of penicillin drugs, which is of great significance to the substance identification of penicillin drugs.
刘晓庆, 姚嘉丽, 黄凡, 刘永基, 林列, 孙陆, 刘伟伟. 基于太赫兹时域光谱的青霉素类药物检测研究[J]. 光学学报, 2020, 40(6): 0630001. Xiaoqing Liu, Jiali Yao, Fan Huang, Yongji Liu, Lie Lin, Lu Sun, Weiwei Liu. Study on Detection of Penicillin Drugs Based on Terahertz Time-Domain Spectroscopy[J]. Acta Optica Sinica, 2020, 40(6): 0630001.