中国激光, 2020, 47 (2): 0207008, 网络出版: 2020-02-21
二次谐波在生物医学成像中的应用 下载: 3367次特邀综述
Application of Second Harmonic Generation in Biomedical Imaging
非线性光学 二次谐波 生物医学成像 生物组织结构 二次谐波探针 nonlinear optics second harmonic generation biomedical imaging biological organizational structure second harmonic generation probe
摘要
二次谐波成像是近年来发展的一种新的光学成像技术,作为生物结构检测和耐久追踪标记的新工具已经受到广泛的关注。二次谐波成像技术避免了经典荧光探针会遇到的许多固有缺点,是一种理想的活体成像方法,具有很好的生物医学应用前景。本文系统介绍了二次谐波原理及其成像装置,二次谐波介质分类及特点,二次谐波在生物医学成像中的应用,最后对二次谐波成像未来的机遇和将要面对的挑战进行了展望。
Abstract
Second harmonic generation (SHG) is a novel optical imaging technology that has been recently developed. SHG has attracted considerable attention as a new tool for the biological structure and durable tracking. The SHG technology eliminates many disadvantages associated with the classical fluorescent probes. It is an ideal in vivo imaging method and exhibits good biomedical application prospects. In this study, we introduce the principle of SHG and its imaging device, classify the SHG media, review the application of SHG in biomedical imaging, and prospect future opportunities and challenges.
张子一, 王明雪, 刘志贺, 房晓峰, 吴长锋. 二次谐波在生物医学成像中的应用[J]. 中国激光, 2020, 47(2): 0207008. Zhang Ziyi, Wang Mingxue, Liu Zhihe, Fang Xiaofeng, Wu Changfeng. Application of Second Harmonic Generation in Biomedical Imaging[J]. Chinese Journal of Lasers, 2020, 47(2): 0207008.