提出一种制造辅助的光学相干层析成像(M-OCT)方法来实现高分辨、无损、全纵深、大体积成像。该方法融合离散制造原理和显微层析成像方法,在离散制造过程中通过OCT获取高分辨率图像,离散制造和OCT扫描同步或交替进行,结合图像拼接算法,在完成制造的同时获取制造样品的三维全纵深图像。利用三维(3D)打印技术构建高分子支架并进行M-OCT验证,成像结果与微计算机断层扫描技术(Micro-CT)结果一致,而M-OCT相比Micro-CT可以更清晰地分辨出相邻层材料堆积融合状态及制造缺陷。基于M-OCT的高分辨率成像结果,量化了整个支架的打印层厚、不同区域的孔径、丝径。大体积、高分辨OCT为3D打印、细胞组装、生物制造、自动切片等离散制造过程的监控及无损检测提供了一种新方法。

A manufacturing-aid optical coherence tomography (M-OCT) method is proposed to achieve imaging with high-resolution, non-destructivity, full-depth, and large-volume. This method combines the discrete manufacturing principle and microtomography. High-resolution images are obtained by OCT in the discrete manufacturing process. OCT scan and discrete manufacturing are conducted simultaneously or alternately, which combines the image mosaic algorithm, the full-depth three-dimensional (3D) image of the manufacturing samples is obtained at the same time as the manufacturing is completed. Polymer scaffolds are constructed using the 3D printing technology for M-OCT verification, and the imaging results are consistent with those of microcomputed tomography (Micro-CT). Moreover, when compared with Micro-CT, M-OCT can more clearly distinguish the stack-fusion state of adjacent layers of materials and the manufacturing defects. The thickness of the printing layer, the pore diameters and the strut diameters of different regions are quantified using the high-resolution imaging results of M-OCT. The large-volume and high-resolution OCT provides a new method for monitoring the discrete manufacturing processes such as 3D printing, cell assembly, biological manufacturing, and automatic biopsy and the non-destructive tests.