浅表组织后向散射检测中偏振门的蒙特卡罗研究

鞠栅; 邓勇; 骆清铭; 鲁强

光学学报, 2007, 27 (8): 1465, 网络出版: 2007-09-05

浅表组织后向散射检测中偏振门的蒙特卡罗研究

Monte Carlo Simulation of Polarization Gating for Superficial Tissue Detection

论文大纲

鞠栅 ^*邓勇骆清铭鲁强

作者单位

华中科技大学生物医学光子学教育部重点实验室,武汉光电国家实验室生物医学光子学研究部, 武汉 430074

医用光学与生物技术偏振门斜入射蒙特卡罗模拟 medical optics and biotechnology polarization gating oblique incidence Monte Carlo simulation

摘要

已有实验表明偏振门和斜入射技术能有效地抑止深层散射光子,实现浅表组织光学特性的检测。采用蒙特卡罗方法,分析了斜入射、偏振门的特性,研究了组织光学参量和入射角等参量对平均探测深度的影响。结果表明,组织的各向异性因子和入射角对平均探测深度影响较大。当各向异性因子较小(小于0.8)或者入射角较大(大于1.4 rad)时,组织的平均探测深度能满足小于2倍平均自由程的要求。偏振门和斜入射技术均可使探测光子经历的散射次数和探测深度有明显减小,因此,结合偏振门和斜入射技术能够更有效地分辨来自浅层的信号光,抑止来自深层的背景光。

Abstract

Previous studies have demonstrated that the techniques of polarization and oblique incidence can effectively suppress the scattered light from deep layer, thus providing feasible methods to detect optical properties of superficial tissue. Monte Carlo simulation is used to study their mechanism. The effects of optical properties and incident angle on detection depth are investigated respectively. It is found that anisotropy factor and incident angle affects the detection depth much. While for the cases of small anisotropy (<0.8) or large incident angle (>1.4 rad), detection depth can be constrained in the depth of less than 2 fold of mean free path. The techniques of polarization and oblique incidence can effectively reduce scattering times and penetration depth of detected photons, which indicates that it can effectively differentiate signal from superficial tissue and remove background signal from underlying tissue through combining these two techniques.

参考文献

[1] . Backman, M. B. Wallace, L. T. Perelman et al.. Detection of preinvasive cancer cells[J]. Nature, 2000, 406(6791): 35-36.

[2] . Gurjar, Vadim Backman, Lev T. Perelman et al.. Imaging human epithelial properties with polarized light scattering spectroscopy[J]. Nature Medicine, 2001, 7(11): 1245-1248.

[3] Yong Deng, Qiang Lu, Qingming Luo. Determining particle size distribution and refractive index in a two-layer tissue phantom by linearly polarized light[J]. Chin. Opt. Lett., 2006, 4(1): 45～48

[4] . Jacques, Jessica C. Ramella-Roman, Ken Lee. Imaging skin pathology with polarized light[J]. J. Biomedical Optics, 2002, 7(3): 329-340.

[5] . . Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ[J]. IEEE J. Sel. Quant. Electron., 1999, 5(4): 1019-1026.

[6] Deng Yong, Lu Qiang, Luo Qingming. Analyses of single backscattering spectra of a two-layer scattering medium[J]. Acta Optica Sinica, 2006, 26(4): 595～599 (in Chinese)
邓勇,鲁强,骆清铭. 双层散射介质的单次后向散射光谱分析[J]. 光学学报, 2006, 26(4): 595～599

[7] Hu Rui, Deng Yong, Lu Qiang et al.. Measurement of the two dimensional diffuse backscattering mueller matrix of turbid medium[J]. Acta Photonica Sinca, 2006, 35(6): 910～914 (in Chinese)
胡锐,邓勇, 鲁强等. 混浊介质二维后向漫散射穆勒矩阵的测量[J]. 光子学报, 2006, 35(6): 910～914

[8] . . Monte Carlo modeling of optical coherence tomography imaging through turbid media[J]. Appl. Opt., 2004, 43(8): 1628-1637.

[9] Ju Shan, Deng Yong, Lu Qiang et al.. Parallel Monte Carlo program for the spectroscopy of polarized light scattering[J]. Acta Optica Sinica, 2007, 27(3): 510～514 (in Chinese)
鞠栅,邓勇,鲁强等. 用于偏振散射光谱术研究的并行蒙特卡罗程序[J]. 光学学报, 2007, 27(3): 510～514

[10] . Schmitt, Gitesh Kumar. Optical scattering properties of soft tissue: a discrete particle model[J]. Appl. Opt., 1998, 37(13): 2788-2797.

[11] . Kim, Xu Li et al.. Investigation of depth selectivity of polarization gating for tissue characterization[J]. Opt. Express, 2005, 13(2): 601-611.

[12] . Chang, Dizem Arifler, Rebekah Drezek et al.. Analytical model to describe fluorescence spectra of normal and preneoplastic epithelial tissue: comparison with Monte Carlo simulations and clinical measurements[J]. J. Biomedical Optics, 2004, 9(3): 511-522.

鞠栅, 邓勇, 骆清铭, 鲁强. 浅表组织后向散射检测中偏振门的蒙特卡罗研究[J]. 光学学报, 2007, 27(8): 1465. 鞠栅, 邓勇, 骆清铭, 鲁强. Monte Carlo Simulation of Polarization Gating for Superficial Tissue Detection[J]. Acta Optica Sinica, 2007, 27(8): 1465.

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