吲哚菁绿与亚甲基蓝对生物组织激光钎焊强度及热损伤的影响 
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Effects of Indocyanine Green and Methylene Blue on Tensile Strength and Thermal Damage of Laser Biological Tissue Soldering
南京理工大学材料科学与工程学院, 江苏 南京 210094
图 & 表
图 1. 实验仪器及样本。(a)生物组织焊接用激光器及热像仪;(b)离体猪皮肤样品及切口焊接位置
Fig. 1. Experimental instrument and sample. (a) Laser for biological tissue welding and thermal imager; (b) skin sample in vitro and welding position
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图 2. 测试仪器及测试过程。(a)测试抗拉强度所用数显式推拉力计;(b)抗拉强度测试过程示意图
Fig. 2. Test instrument and test processing. (a) Digital explicit push-pull force meter for measuring tensile strength; (b) diagram of process for measuring tensile strength
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图 3. 亚甲基蓝实验组焊接试样的宏观形貌。(a)焊后切口正面;(b) 焊后切口反面;(c)焊后切口侧面
Fig. 3. Macroscopic morphologies of welded specimens of methylene blue test group. (a) Front of welded incision; (b) reverse side of welded incision; (c) side of welded incision
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图 4. 吲哚菁绿实验组焊接试样的宏观形貌。(a)焊后切口正面;(b)焊后切口反面;(c)焊后切口侧面
Fig. 4. Macroscopic morphologies of welded specimens of indocyanine green test group. (a) Front of welded incision; (b) reverse side of welded incision; (c) side of welded incision
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图 5. 将不同的生物染料施加于切口正、反面时切口抗拉强度的平均值
Fig. 5. Average tensile strength of welded incisions with different biological dyes
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图 6. 将不同的生物染料施加于切口正、反面时切口抗拉强度的最大值
Fig. 6. Maximum tensile strength of welded incisions with different biological dyes
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图 7. 亚甲基蓝浓度及施加位置对切口抗拉强度的影响
Fig. 7. Effects of methylene blue concentration and applied position on tensile strength
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图 8. 吲哚菁绿质量浓度及施加位置对切口抗拉强度的影响
Fig. 8. Effects of indocyanine green concentration and applied position on tensile strength
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图 9. 不同染料和不同施加位置下测量点的平均温度
Fig. 9. Average temperature of measuring points of different dyes at different applied positions
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表 1激光焊接生物组织的工艺参数
Table1. Process parameters of laser welding for biological tissue
| Power /W | Pulsefrequency /kHz | Weldingspeed /(mm·s-1) | Weldingtime /s |
|---|
| 4 | 100 | 100 | 1200 |
|
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表 2染料种类、质量浓度及位置分布
Table2. Type, mass concentration, and location distribution of dyes
| Type of dyes | Mass concentration /(mg·L-1) |
|---|
| Surface | Back |
|---|
| 50 | 50 | | 100 | 100 | | Indocyanine green | 150 | 150 | | 200 | 200 | | 250 | 250 | | 50 | 50 | | 100 | 100 | | Methylene blue | 150 | 150 | | 200 | 200 | | 250 | 250 |
|
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表 3亚甲基蓝实验组的抗拉强度
Table3. Tensile strength of methylene blue test group
| Mass concentration of methylene blue /(mg·L-1) | Tensile strength /(N·cm-2) |
|---|
| Surface | Back |
|---|
| 50 | 14.93±1.22 | 8.08±0.89 | | 100 | 11.10±0.92 | 10.00±0.93 | | 150 | 11.73±0.78 | 9.60±1.30 | | 200 | 11.20±0.83 | 7.80±1.62 | | 250 | 10.60±1.13 | 6.78±0.91 |
|
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表 4吲哚菁绿实验组的抗拉强度
Table4. Tensile strength of indocyanine green test group
| Mass concentration of indocyanine green /(mg·L-1) | Tensile strength /(N·cm-2) |
|---|
| Surface | Back |
|---|
| 50 | 11.18±0.80 | 8.60±0.91 | | 100 | 10.88±1.23 | 8.90±1.06 | | 150 | 15.15±1.21 | 9.15±1.30 | | 200 | 13.00±1.35 | 11.90±0.66 | | 250 | 10.93±0.95 | 9.55±0.90 |
|
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表 5不同染料和不同施加位置下测量点的热损伤值
Table5. Thermal damage of measuring points of different dyes at different applied positions
| Appliedposition | Thermal damage |
|---|
| Controlgroup | Methyleneblue | Indocyaninegreen |
|---|
| Surface | 5881 | 740 | 11.7 | | Back | 5881 | 934 | 46.9 |
|
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李聪, 王克鸿, 黄俊. 吲哚菁绿与亚甲基蓝对生物组织激光钎焊强度及热损伤的影响[J]. 中国激光, 2019, 46(12): 1207002. Cong Li, Kehong Wang, Jun Huang. Effects of Indocyanine Green and Methylene Blue on Tensile Strength and Thermal Damage of Laser Biological Tissue Soldering[J]. Chinese Journal of Lasers, 2019, 46(12): 1207002.
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