基于太赫兹光谱的固体片剂孔隙率研究 
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Porosity of Tablets Based on Terahertz Spectroscopy
1 天津大学精密测试技术及仪器国家重点实验室, 天津 300072
2 天津大学太赫兹研究中心, 天津 300072
图 & 表
图 1. 多孔固体片剂示意图
Fig. 1. Schematic of porous tablet
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图 2. 片剂孔隙率、不同成分质量分数、折射率的数学模型
Fig. 2. Simulated mathematical model showing the relationship between porosity of tablets, mass fractions of different compositions and refractive index
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图 3. 片剂的太赫兹脉冲信号。 (a)时域谱; (b)频域谱
Fig. 3. Terahertz pulse signals of tablet. (a) Time-domain spectra; (b) frequency-domain spectra
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图 4. (a)第1组片剂折射率与厚度的实验结果;(b)第2组片剂折射率与孔隙率的实验结果;(c)第3组片剂折射率与API质量分数的实验结果
Fig. 4. (a) Experimental results of refractive index and thickness of tablets in the first group; (b) experimental results of refractive index and porosity of tablets in the second group; (c) experimental results of refractive index and API mass fraction of tablets in the third group
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图 5. 外推法求零孔隙率时的nMCC和nAPI。(a)由第3组数据得到API质量分数为7.1%时的MCC和API的折射率;(b)零孔隙率时MCC和API的折射率
Fig. 5. Refractive indexes of MCC and API obtained by linear extrapolation when porosity is zero. (a) Refractive indexes of MCC and API obtained by the third group data when the mass fraction of API is 7.1%; (b) refractive indexes of MCC and API when porosity is zero
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图 6. 片剂孔隙率的理论计算值与实验测量值。(a)第1组; (b)第2组; (c)第3组
Fig. 6. Calculated and experimental porosities of tablets. (a) The first group; (b) the second group; (c) the third group
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表 1第1组实验片剂的参数(厚度不同)
Table1. Parameters of tablets with different thicknesses in the first group
| No. | m /mg | d /mm | H /mm | x /% | /% |
|---|
| 1 | 360.36 | 13.0744 | 1.8780 | 10 | 7.0 | | 2 | 440.40 | 13.0690 | 2.2788 | 10 | 6.2 | | 3 | 480.13 | 13.0670 | 2.5004 | 10 | 6.8 | | 4 | 520.60 | 13.0678 | 2.6952 | 10 | 6.3 |
|
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表 2第2组实验片剂的参数(孔隙率不同)
Table2. Parameters of tablets with different porosities in the second group
| No. | m /mg | d /mm | H /mm | x /% | /% |
|---|
| 1 | 341.11 | 13.0556 | 1.7798 | 10 | 6.81 | | 2 | 355.41 | 13.0504 | 1.8604 | 10 | 7.04 | | 3 | 362.35 | 13.0758 | 1.8922 | 10 | 7.18 | | 4 | 370.32 | 13.0544 | 1.9292 | 10 | 6.65 | | 5 | 376.45 | 13.0636 | 1.9490 | 10 | 6.20 | | 6 | 385.35 | 13.0598 | 2.0028 | 10 | 6.51 | | 7 | 391.69 | 13.0576 | 2.0400 | 10 | 6.67 |
|
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表 3第3组实验片剂的参数(API质量分数不同)
Table3. Parameters of tablets with different API mass fractions in the third group
| No. | m /mg | d /mm | H /mm | x /% | /% |
|---|
| 1 | 401.31 | 13.0778 | 2.073 | 0 | 7.5 | | 2 | 400.48 | 13.0670 | 2.081 | 5 | 7.2 | | 3 | 400.00 | 13.0652 | 2.087 | 10 | 6.9 | | 4 | 401.11 | 13.0638 | 2.113 | 15 | 7.2 | | 5 | 400.19 | 13.0714 | 2.107 | 20 | 6.6 | | 6 | 399.95 | 13.0734 | 2.124 | 25 | 6.8 | | 7 | 399.81 | 13.0898 | 2.138 | 30 | 7.1 | | 8 | 400.34 | 13.0828 | 2.156 | 35 | 7.1 |
|
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表 4分别改变孔隙率与API质量分数时折射率改变量的理论与实验值
Table4. Theoretical and experimental changes of refractive index obtained by changing porosity and API mass fraction respectively
| Item | Δneff |
|---|
| Δp=1% | Δx=35% |
|---|
| Theoretical change | 0.0081 | 0.0301 | | Experimental change | 0.0152 | 0.0298 |
|
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赖慧彬, 何明霞, 田甜, 孙珑玲. 基于太赫兹光谱的固体片剂孔隙率研究[J]. 光学学报, 2018, 38(6): 0630001. Huibin Lai, Mingxia He, Tian Tian, Longling Sun. Porosity of Tablets Based on Terahertz Spectroscopy[J]. Acta Optica Sinica, 2018, 38(6): 0630001.
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