超灵敏原子磁力计在生物磁应用中的研究进展 
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Progress in Biomagnetic Signal Measurements with Ultra-Sensitive Atomic Magnetometers
1 中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室， 湖北 武汉 430071
2 中国科学院大学， 北京 100049
图 & 表
图 1. 超灵敏原子磁力计原理图
Fig. 1. Schematic diagram of ultra-sensitive atomic magnetometer
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图 2. 光抽运原理图
Fig. 2. Schematic diagram of optical pumping
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图 3. NMOR原理图
Fig. 3. Schematic diagram of NMOR
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图 4. 神经冲动产生传导电流和体电流(体电流产生电信号和传导电流产生磁信号)原理图
Fig. 4. Schematic diagram of nerve impulse generating conduction current and volume current (electric signals arise from the volume current, while magnetic signals arise from the conduction current)
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图 5. 生物磁磁感应强度
Fig. 5. Magnetic field strength of biomagnetism
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图 6. MCG波型示例
Fig. 6. Example of MCG waveform
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图 7. 心磁探测阵列原理图及其预估信号
Fig. 7. Schematic diagram of MCG and predicted MCG
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图 8. 脑磁探测原理图
Fig. 8. Schematic diagram of MEG
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图 9. 超灵敏原子磁力计测量动物神经冲动原理图
Fig. 9. Schematic diagram of ultra-sensitive atomic magnetometer detecting animal nerve impulses
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表 1原子磁力计测量不同特征生物磁获得的强度
Table1. Amplitudes of various biomagnetic features obtained by atomic magnetometer
| Type | Feature | Date | Author | Distance /mm | Field amplitude /pT | |
|---|
| MCG | QSR | 2014 | Bison et al. | — | about 50[16] | | | 2010 | Knappe et al. | 50 (from the heart)5 (from the skin) | about 180[44] | | | 2012 | Wyllie et al. | 76 (from the heart)10 (from the skin) | about 40[45] | | | fMCG | QSR | 2012 | Wyllie et al. | — | about 1.5[17] | | | 2015 | Alem et al. | 4.5 (from the skin) | about 40[46] | | | 2017 | Eswaran et al. | — | about 4[47] | | | MEG | Evoked response | 2006 | Xia et al. | 25 (from the scalp) | about 1.2[18] | | | SpontaneousEvoked response | 2012 | Sander et al. | 25 (from the source) | about 0.5[48]about 2[48] | | | 2013 | Shah et al. | 5-25 (from the scalp) | 0.1-0.2[42] | | | Evoked response | 2013 | Johnson et al. | 30 (from the scalp) | about 0.2[19] | | | 2017 | Sheng et al. | 6 (from the scalp) | about 1.2[49] | | | 2017 | Boto et al. | 6.5 (from the scalp) | about 2[50] | | | Nerve | Nerve pulse | 2016 | Jensen et al. | 1.9 | about 24[51] | |
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王晓飞, 孙献平, 赵修超, 朱茂华, 叶朝辉, 周欣. 超灵敏原子磁力计在生物磁应用中的研究进展[J]. 中国激光, 2018, 45(2): 0207012. Wang Xiaofei, Sun Xianping, Zhao Xiuchao, Zhu Maohua, Ye Chaohui, Zhou Xin. Progress in Biomagnetic Signal Measurements with Ultra-Sensitive Atomic Magnetometers[J]. Chinese Journal of Lasers, 2018, 45(2): 0207012.
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