改性羧甲基壳聚糖复合材料的制备、表征与研究

为了提高壳聚糖的水溶性及其止血方面的性能, 将壳聚糖(CS)进行羧甲基化改性, 并引入具有抗菌作用的Ag+和TiO2, 制备出羧甲基壳聚糖复合止血材料。首先, 在壳聚糖中引入羧甲基, 制得羧甲基壳聚糖(CMCS), 之后向其中引入Ag+和TiO2, 分别制备出Ag+-CMCS、TiO2-CMCS和Ag+ -TiO2-CMCS复合材料。然后, 采用 FTIR、XRD、SEM等手段对复合材料的结构进行表征。最后, 对复合物的凝血、止血性能进行了测试。实验结果表明: 改性后的羧甲基壳聚糖的IR图谱在3 423 cm-1和1 380 cm-1处出现了羧甲基壳聚糖钠盐的特征吸收峰。改性后的羧甲基壳聚糖在XRD图谱中表现出了金属晶态。CMCS的粒径为14.8 nm左右, Ag+粒径为143.5 nm左右, 纳米TiO2的粒径为267.2 nm左右, 且三者分散的很均匀。Ag+-TiO2-CMCS的凝血、止血效果要优于Ag+-CMCS和TiO2-CMCS, 同时Ag+-CMCS和TiO2-CMCS的凝血、止血效果要优于CMCS。

Abstract

In order to improve the water soluble and the hemostatic performance of chitosan, the chitosan(CS) was modified by carboxymethylation, and Ag+ and TiO2 with antibacterial action were introduced. In this way, carboxymethyl chitosan composite hemostatic material was prepared. Firstly, in chitosan, carboxymethyl was introduced, and carboxymethyl chitosan(CMCS) was prepared, then Ag+ and TiO2 were introduced, and Ag+-CMCS, TiO2-CMCS and Ag+-TiO2-CMCS composites were prepared, respectively. Then, FTIR, XRD and SEM were used to characterize the structure of composites. Finally, the coagulation and hemostatic properties of the complex were tested. There are characteristic absorption peaks of carboxymethyl chitosan sodium salt around 3 423 cm-1 and 1 380 cm-1 in the IR spectra of modified carboxymethyl chitosan. The XRD shows it is metals crystalline. The average diameter of CMCS is about 14.8 nm, Ag+ is 143.5 nm, nanometre TiO2 is 267.2 nm, and all of them are homodisperse. The properties of crour and hemostasis of Ag+-TiO2-CMCS are superior to Ag+-CMCS and TiO2-CMCS, while Ag+-CMCS and TiO2-CMCS also have an advantage over CMCS.

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董丽丹, 魏长平, 李中田, 汪凤明. 改性羧甲基壳聚糖复合材料的制备、表征与研究[J]. 发光学报, 2018, 39(9): 1207. DONG Li-dan, WEI Chang-ping, LI Zhong-tian, WANG Feng-ming. Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite[J]. Chinese Journal of Luminescence, 2018, 39(9): 1207.

改性羧甲基壳聚糖复合材料的制备、表征与研究

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