散光会导致视力降低、视物疲劳, 影响视觉质量。很多患者放弃配戴球面软性接触镜的主要原因是由于不能忍受残余散光带来的视觉影响, 而配戴环曲面设计的软性角膜接触镜可以为患者带来视觉体验的提升。本研究通过对比G&G POP·CT和艾爵NT38两款散光软镜在矫正视力、残余屈光度、配适状态、安全性、配戴舒适性、视觉症状、患者满意度等方面的表现, 验证散光软镜的临床效果。

虹膜纹理容易被纹理隐形眼镜隐藏甚至伪造，进而对虹膜识别系统的安全性构成了威胁。针对真实虹膜与纹理隐形眼镜伪造虹膜光学特性和纹理特征差异较小的问题，提出了一种循环注意力隐形眼镜虹膜防伪检测方法RAINet。利用循环注意力机制对能区分真伪虹膜的关键区域进行无监督定位，并通过多层级特征融合提升防伪检测精度，构建了端到端防伪检测网络，无需图像预处理即可直接进行真伪特征检测。采用MobileNetV2作为特征分类网络，在保持检测精度的同时，减少了网络的参数量和计算量。在包含真实虹膜样本和隐形眼镜虹膜样本的两个公开数据库（IIITD CLI和ND系列）上进行了实验验证。结果表明，RAINet的检测精度优于其他防伪检测网络，在同传感器、跨传感器和跨数据库实验条件下的平均正确分类率分别可达到99.93%、97.31%和97.86%。

为控制青少年的近视进展并矫正近视并发散光,设计一款多区域非球面隐形眼镜。运用Zemax构建了-3 D(屈光度)近视联合-1.5 D散光的眼模型,基于此模型分别优化了隐形眼镜前表面各区域的面型参数,得到一款直径为14.4 mm、中心厚度为0.06678 mm的隐形眼镜,并分析佩戴此隐形眼镜眼模型的成像性能及周边离焦情况。结果表明,眼模型在3 mm(直径)瞳孔下视远时,空间频率50 cycle/mm处的调制传递函数(MTF)在0°~7°视场内均高于0.7,表明近视和散光均得到良好矫正。当隐形眼镜出现30°以内的旋转或0.7 mm以内的偏心时,佩戴隐形眼镜的眼模型的成像性能保持相对稳定。此外,眼模型在3 mm瞳孔下25°视场的离焦值高达-9.5 D;在6 mm瞳孔下0°~30°视场内的离焦值均在-6 D左右,表明此款隐形眼镜提供了较大的周边近视性离焦值,具有控制近视进展的潜力。

为解决眼底相机在进行视网膜疾病筛查时视场角较小的问题,设计了一种基于角膜接触眼底镜、利用多环光纤实现广域照明的视网膜广域成像系统。对该系统所采用的眼模型、广域成像及照明方式等进行了研究。首先,为实现系统充分照明,设计了多环光纤照明结构;接着为模拟人眼广域成像原理,结合婴幼儿眼球结构特点建立了Escudero-Sanz大视场眼模型;然后设计了角膜接触眼底镜,采用像差小、折射率大的非球面设计,满足大视场的要求;最后搭建了实验平台。实验结果表明：设计的角膜接触眼底镜可以实现85°视场的广域成像，采用多环光纤光线照明可以得到较清晰的视网膜及其周边血管图像。

近视人眼随年龄的增长会出现老视, 为了实现一副眼镜矫正近视并发老视人眼的远、近视力, 设计了一种非球面衍射型隐形眼镜(CL), 通过非球面CL矫正近视, 并通过衍射环的设计矫正老视。在一个有200度近视和2 D调节力的近视并发老视眼模型上优化CL, 选取的5个设计物距介于250 mm到无限远。研究了0°视场和±4°视场时设计物距下佩戴CL的近视并发老视眼模型的光学性能。结果表明, 佩戴该CL后, 在明视觉条件下(2.8 mm瞳孔直径), 注视不同距离物体时, 人眼视力最低可达1.3, 最高可达1.5; 在间视觉条件下(4.5 mm瞳孔直径), 除注视无穷远处物体时视力略差(0.9), 注视其他距离物体时, 视力均在1.0以上。此外, 佩戴CL后, 眼模型的大视场彗差、像散和畸变均在合理范围内。可见, 所设计CL能够在0~4 D物距范围内提供良好的光学质量和视觉质量, 且中间距离也实现了高质量成像, 成像性能几乎不受瞳孔变化的影响。

Purpose: The examination of the effects of second generation lotrafilcon B silicone hydrogel (SiH) lenses on the cornea when worn for three years of daily wear. Material and Methods: 55 healthy patients were divided into two groups: current hydrogel contact lens wearers refitted with lotrafilcon B lenses (Group 1; 28 patients) and neophyte contact lens wearers (Group 2; 27 patients). Each patient's subjective eye comfort was measured with a self-administered questionnaire. The corneas were analyzed using contact specular microscope to measure corneal thickness and the endothelium before the SiH lenses were fitted after four weeks, one month, six months, one year, two years, and three years of lens wear. Results: Subjective complaints of patients in Group 1 were reduced; however patients in Group 2 experienced discomfort during the first two to four weeks of use. In Group 1, objective examinations identified a decrease in endothelial cell density. In Group 2, the endothelial cell density increased slightly in the first two years but decreased after three years. The results indicate that lotrafilcon B slows down the deleterious effects of contact lenses. The coefficient of variation significantly decreased after six months in Group 1 (0.47 vs 0.44; p = 0.049), whereas, in Group 2, the hexagonal cells improved significantly after one month (27.78 vs 28.25; p = 0.025). Conclusion: Based on the subjects involved and the period of time under examination, it can be concluded that high-Dk SiH lenses support the physiological metabolism and functions of the cornea by improving oxygen provision.

Purpose: To investigate the effects of rigid-gas-permeable contact lens (RGP-CL) wear on Zernike astigmatism and visual performance in myopic eyes. Methods: A wavefront sensor was used to evaluate Zernike astigmatism for 21 eyes with minimum astigmatism and 18 eyes with moderate astigmatism under three different modes of refractive correction: the RGP-CL, spectacle lens correcting spherical equivalent (SL) and spectacle lens fully correcting spherical error and astigmatism (fSL). Contrast visual acuity was assessed with a VA tester at four contrast levels and two luminance backgrounds. Results: Compared to the SL wear, RGP-CL wear changed the main axis astigmatism (Z²₂ ) from -0.09 ± 0.34 to 0.34±0.22 for the minimum astigmatism group, while the contrast VA was improved about 0.05 LogMAR (F = 8.06, p < 0.01). For the group with moderate astigmatism, significant reduction in Z²₂ was found for both fSL wear (t = 4.78, p < 0.001) and RGP-CL wear (t = 6.29, p < 0.0001). The changes in astigmatism were significantly correlated between the fSL and RGP-CL wears (r = 0.897, p < 0.0001 for Z^-2₂ ; and r = 0.643, p = 0.004 for Z²₂) . Contrast VA was significantly improved for both fSL and RGP-CL wears and the improvements were significantly correlated between each other for all four contrast levels and two backgrounds. Conclusion: RGP-CL wear induces astigmatism for the eyes with minor astigmatism probably due to a correction of corneal astigmatism and thus a manifesting of the lens astigmatism. For the astigmatic eyes, RGP-CL wear has similar effect on correcting astigmatism as the spectacle lens wear with spherical-cylinder correction and also produces similar visual improvement.

提出了一种客观验光的波前角膜接触镜的设计方法。采用角膜地形图数据，最优化拟合得到角膜接触镜的后表面面型结构；采用眼波前像差数据，运用波前在介质中传播的衍射光学的角谱理论，结合泪液透镜的作用，最优化设计角膜接触镜的前表面面型结构；根据角膜接触镜前后表面的结构，计算得角膜接触镜的最优矫正光焦度。为8只具有不同程度离焦和像散的近视眼设计了波前角膜接触镜，对角膜接触镜光焦度的分析表明，接触镜后表面为球面面型设计的，其接触镜的光焦度等于人眼的光焦度与泪液镜光焦度之和，而对于镜片后表面为环曲面面型设计的，其接触镜光焦度与全眼光焦度匹配，验证了结果的合理性。

提出了对软性亲水性接触镜采用非接触的光电成像检测方法．将浸于液体中的软性亲水性接触镜置于高准确度的标准环上，采用投影光学系统将其投影放大，并用光电图像探测器接收软性亲水性接触镜的放大图像．通过计算机图像处理、计算出放大后的图像尺寸，然后利用成像公式、标准环的尺寸等相关参量，最终计算出软性亲水性接触镜的实际几何参量．采用放大倍率为20倍的投影成像光学系统，像元中心距为50μm、像元数为512位的CCD线阵，51系列单片机进行数据处理．经计算，该光电成像测量系统对软性亲水性接触镜的中心厚度、曲率半径的测量分辨力达到了0．005mm，远高于系统0．01mm的准确度要求．