半导体光电, 2017, 38 (6): 784, 网络出版: 2017-12-25  

CMOS荧光波长检测芯片的设计与仿真

Design and Simulation of CMOS Fluorescence Chip for Wavelength Detection
作者单位
浙江工业大学 信息学院, 杭州 310023
摘要
双结深光电二极管包括一深一浅两个光电二极管, 深、浅pn结光电二极管的光电流比值I2/I1随入射光波长单调增加。文章基于0.5 μm CMOS工艺对双结深光电二极管深、浅结光电流进行了数学建模和Matlab仿真。设计了片上信号处理电路, 将双结深光电二极管深、浅结光电流比值转换成电压输出。仿真结果表明, 信号处理电路的输出与ln(I2/I1)具有良好的线性关系。单片集成的CMOS波长检测芯片可用于未知荧光的波长检测和特异性分析。
Abstract
Double junction photodiode includes one deep and one shallow pn junctions, and the optimal current ratio I2/I1 between deep and shallow junctions increases with the raise of the incident wavelength. In this paper, the mathematical modeling and Matlab simulation of the photocurrent for deep and shallow junction diodes are realized based on 0.5 μm CMOS technology. The current ratio of deep and shallow junction for double junction photodiode is converted to the voltage by the integrated signal processing circuits. The simulation results show that the output of the signal processing circuits has a good linear relationship with the natural logarithm of ln(I2/I1). The monolithic integrated CMOS wavelength detection chip can be used for the detection and analysis of unknown wavelength.
参考文献

[1] Ti Jia, Chusen Huang. Fluorescence polarization mode with naphthalimide: A new fluorescent toolbox for direct detection of cancer cells[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12(2): 475. 南妙晴, 王 爽, 王凯歌, 等. 皮肤基底细胞癌症组织荧光特性理论模拟与分析[J]. 光子学报, 2013, 42(9): 1129-1134.

    Nan Miaoqing, Wang Shuang, Wang Kaige, et al. Theoretical study on autofluorescence characteristics of skin basal cell carcinoma[J]. Acta Photonica Sinica, 2013, 42(9): 1129-1134.

[2] 李 静. 癌细胞和血液的特征荧光光谱研究[D]. 成都: 电子科技大学, 2009.

    Li Jing. Spectrofluorimetry study on characteristics of cancer cells and blood[D]. Chengdu: University of Electronic Science and Technology of China, 2009.

[3] Hu Jingqiu, Xia Bing, Elioff M S. A new terthiophene derivative as a fluorescent sensor for protein detection[J]. J. Luminescence., 2016, 173: 57-65.

[4] Ferry Heus, Martin Giera, Gerdien E, et al. Development of a micro fluidic co-focal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays[J]. Anal. Bioanal. Chem., 2010, 398: 3023-3032.

[5] 张 雯, 钱金雄, 肖彦革, 等. 微流控芯片荧光检测系统研究进展[J]. 理化实验: 化学分册, 2011, 47(12): 1495-1500.

    Zhang Wen, Qian Jinxiong, Xiao Yange, et al. Advance of fluorescence detection system in microfluidic chip[J]. Physical Testing and Chemical Analysis Part B: Chemical Analasis, 2011, 47(12): 1495-1500.

[6] Zhan Zhiyong, Zhou Bin, Fu Zhenhong, et al. Filterless optical oxygen sensor based on a CMOS buried double junction photodiode[J]. Sensors and Actuators B: Chemical, 2013,176: 729-735.

[7] 刁 静. 有源像素CMOS图像传感器的设计研究[D]. 成都: 电子科技大学, 2006.

    Diao Jing. Study on active CMOS image sensor[D]. Chengdu: University of Electronic Science and Technology of China, 2006.

施朝霞, 吴柯柯, 李如春, 曹全君. CMOS荧光波长检测芯片的设计与仿真[J]. 半导体光电, 2017, 38(6): 784. SHI Zhaoxia, WU Keke, LI Ruchun, CAO Quanjun. Design and Simulation of CMOS Fluorescence Chip for Wavelength Detection[J]. Semiconductor Optoelectronics, 2017, 38(6): 784.

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!